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Do prevention interventions reduce HIV risk behaviours among people living with HIV? A meta-analytic review of controlled trials

Crepaz, Nicolea; Lyles, Cynthia Ma; Wolitski, Richard Ja; Passin, Warren Fa; Rama, Sima Ma; Herbst, Jeffrey Ha; Purcell, David Wa; Malow, Robert Mb; Stall, Rona,*; for the HIV/AIDS Prevention Research Synthesis (PRS) Team

doi: 10.1097/01.aids.0000196166.48518.a0
Editorial Review

Objective: To conduct a meta-analytic review of HIV interventions for people living with HIV (PLWH) to determine their overall efficacy in reducing HIV risk behaviours and identify intervention characteristics associated with efficacy.

Methods: Comprehensive searches included electronic databases from 1988 to 2004, hand searches of journals, reference lists of articles, and contacts with researchers. Twelve trials met the stringent selection criteria: randomization or assignment with minimal bias, use of statistical analysis, and assessment of HIV-related behavioural or biologic outcomes at least 3 months after the intervention. Random-effects models were used to aggregate data.

Results: Interventions significantly reduced unprotected sex [odds ratio (OR), 0.57; 95% confidence interval (CI) 0.40–0.82] and decreased acquisition of sexually transmitted diseases (OR, 0.20; 95% CI, 0.05–0.73). Non-significant intervention effects were observed for needle sharing (OR, 0.47, 95% CI, 0.13–1.71). As a whole, interventions with the following characteristics significantly reduced sexual risk behaviours: (1) based on behavioural theory; (2) designed to change specifically HIV transmission risk behaviours; (3) delivered by health-care providers or counsellors; (4) delivered to individuals; (5) delivered in an intensive manner; (6) delivered in settings where PLWH receive routine services or medical care; (7) provided skills building, or (8) addressed a myriad of issues related to mental health, medication adherence, and HIV risk behaviour.

Conclusion: Interventions targeting PWLH are efficacious in reducing unprotected sex and acquisition of sexually transmitted diseases. Efficacious strategies identified in this review should be incorporated into community HIV prevention efforts and further evaluated for effectiveness.

From the aDivision of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia

bFlorida International University, Miami, Florida.

*Current address: University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Received 17 May, 2005

Revised 17 August, 2005

Accepted 24 August, 2005

Correspondence to Dr N. Crepaz, Centers for Disease Control and Prevention, Division of HIV/AIDS Prevention, Prevention Research Branch, 1600 Clifton Rd, Mailstop E-37, Atlanta, Georgia, 30333, USA. E-mail:

© 2006 Lippincott Williams & Wilkins, Inc.