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Hepatitis C virus infection and mixed cryoglobulinaemia vasculitis: a review of neurological complications

Cacoub, Patricea; Saadoun, Davida; Limal, Nicolasa; Léger, Jean Marcb; Maisonobe, Thierryb

Section III: Neurological and neuropsychiatric complications

Chronic liver disease caused by hepatitis C virus (HCV) infection is commonly associated with extrahepatic manifestations, mainly mixed cryoglobulinaemia. Neurological complications in HCV-infected patients occur predominantly in the peripheral nervous system. Peripheral neuropathy in HCV infection is primarily associated with mixed cryoglobulinaemia. Central nervous system (CNS) involvement is more rarely reported. In this review, peripheral and CNS involvement associated with chronic HCV infection are described. The underlying mechanisms and treatment possibilities are discussed.

From the aDepartments of Internal Medicine

bNeurology, Hôpital La Pitié-Salpêtrière, Paris, France.

Correspondence to Professor Patrice Cacoub, Department of Internal Medicine, Hôpital La Pitié-Salpêtrière, 83 Boulevard de l'Hôpital, 75651 Cedex 13 Paris, France. Tel: +33 1 42 17 80 27; fax: +33 1 42 17 80 33; e-mail:

© 2005 Lippincott Williams & Wilkins, Inc.