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In vitro suppression of latent HIV-1 activation by vitamin E: potential clinical implications

Heredia, Alonso; Davis, Charles; Amoroso, Anthony; Taylor, Greg; Le, Nhut; Bamba, Douty; Redfield, Robert R

Research Letters

We evaluated the effect of vitamin E in controlling HIV-1 production upon activation of the patients’ reservoir of resting CD4 lymphocytes in tissue culture experiments. The addition of vitamin E to patients’ cultures resulted in significantly reduced levels of p24 virus production (P = 0.0015). These results suggest that vitamin E supplementation may interfere with the emergence of drug-resistant HIV-1 variants archived in the resting cell reservoir and delay or limit virus rebound upon treatment interruptions.

Division of Clinical Research, Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, MD, USA.

Received 10 December, 2004

Accepted 18 February, 2005

© 2005 Lippincott Williams & Wilkins, Inc.