A cross-sectional study was conducted to compare patients treated with tenofovir with patients never treated with tenofovir. Patients on tenofovir showed a lower mean glomerular filtration rate estimated by creatinine clearance or cystatin C clearance compared with control patients. In total, 24 patients on tenofovir versus five control patients had proteinuria greater than 130 mg/day. In the majority of patients on tenofovir proteinuria was of tubular origin.
Center for HIV and Hepatogastroenterology, Duesseldorf; Germany
Received 7 July, 2004
Revised 15 August, 2004
Accepted 1 September, 2004
Sponsorship: This study was supported by an unrestricted grant from Gilead Sciences, Martinsried, Germany.