Institutional members access full text with Ovid®

Antiretroviral therapy with tenofovir is associated with mild renal dysfunction

Mauss, Stefan; Berger, Florian; Schmutz, Guenther

Research Letter

A cross-sectional study was conducted to compare patients treated with tenofovir with patients never treated with tenofovir. Patients on tenofovir showed a lower mean glomerular filtration rate estimated by creatinine clearance or cystatin C clearance compared with control patients. In total, 24 patients on tenofovir versus five control patients had proteinuria greater than 130 mg/day. In the majority of patients on tenofovir proteinuria was of tubular origin.

Center for HIV and Hepatogastroenterology, Duesseldorf; Germany

Received 7 July, 2004

Revised 15 August, 2004

Accepted 1 September, 2004

Sponsorship: This study was supported by an unrestricted grant from Gilead Sciences, Martinsried, Germany.

© 2005 Lippincott Williams & Wilkins, Inc.