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Improved survival in HIV-related Hodgkin's lymphoma since the introduction of highly active antiretroviral therapy

Gérard, Laurencea; Galicier, Lionela; Boulanger, Emmanuellea; Quint, Laurenta; Lebrette, Marie-Giselleb; Mortier, Emmanuelc; Meignin, Véroniqued; Oksenhendler, Erica

Epidemiology & Social

Objective: To evaluate the evolving characteristics of HIV-related Hodgkin's lymphoma (HL) and survival of affected patients since the introduction of highly active antiretroviral therapy (HAART).

Design and methods: A retrospective single-institution study was performed over a 15-year follow-up period. For statistical analysis, patients were categorized into a pre-HAART period (1987–1996, n = 61) and a post-HAART period (1997–2001, n = 47).

Results: HL characteristics were similar in both groups. The chemotherapy regimens used did not differ significantly, although the MOPP/ABV regimen (mechlorethamine, vincristine, procarbazine substituted by cyclophosphamide since 2000, and prednisone /adriamycin, bleomycin, vinblastin) has progressively replaced the ABVD regimen (adriamycin, bleomycin, vinblastin, dacarbazine). A slight increase in the complete response rate was noted in the post-HAART population (74.5%) versus the pre-HAART population (64.5%), and the probability to relapse was not different between the two groups. Patients diagnosed since 1997 had a higher probability for prolonged survival with a median survival time not reached versus 19 months in the pre-HAART period. The estimate 2-year survival probability was 45% [95% confidence interval (CI), 32.3–57.8% in the pre-HAART period, and 62% (95% CI, 46.7–77.1%) in the post-HAART period (P = 0.03). This decreased mortality was associated with a decrease in AIDS-associated deaths. In the post-HAART period, 12 patients were naive to any antiretroviral therapy and 31 were already on HAART at the time of HL diagnosis. Twenty of them had a plasma HIV-RNA below 500 copies/ml. The response rate and the overall survival were not statistically different in these patients.

Conclusions: HL still occurs in patients with HAART-induced HIV suppression. However, overall survival has significantly improved since the introduction of HAART.

From the aService d'Immuno-Hématologie and dLaboratoire d'Anatomopathologie, Hôpital Saint-Louis, Assistance Publique – Hôpitaux de Paris, Paris, the bService des Maladies Infectieuses. Hôpital Rothschild, Assistance Publique – Hôpitaux de Paris, Paris and the cService des Maladies Infectieuses. Hôpital Louis Mourier, Assistance Publique – Hôpitaux de Paris, Colombes, France.

Correspondence to Laurence Gérard, MD, Service d'Immuno-Hématologie, Hôpital Saint-Louis, 1 avenue Claude Vellefaux, 75010 Paris, France. Tel/fax: +33 1 42 49 47 31; e-mail:

Received: 17 April 2002; revised: 25 July 2002; accepted: 12 August 2002.

© 2003 Lippincott Williams & Wilkins, Inc.