Skip Navigation LinksHome > October 19, 2001 - Volume 15 - Issue 15 > Elevated blood pressure in subjects with lipodystrophy
Clinical Science

Elevated blood pressure in subjects with lipodystrophy

Sattler, Fred R.; Qian, Dajuna; Louie, Stanb; Johnson, Debra; Briggs, William; DeQuattro, Vincentc*; Dube, Michael P.d

Collapse Box


Objectives: To assess the prevalence of elevated blood pressure in patients with lipodystrophy.

Design: Case–control study.

Participants: Forty-two patients with abnormal body fat (100%) and serum lipids (86%) (HIV-positive cohort) were matched by age and sex to 42 HIV-positive controls without previously diagnosed lipodystrophy and to 13 HIV-negative controls.

Setting: Tertiary care, university-based, fully dedicated HIV clinic.

Main outcome measures: Frequency and magnitude of elevated blood pressure during highly active antiretroviral therapy.

Results: There were 23 ± 16 and 22 ± 12 blood pressure measurements recorded per subject over 21 ± 11 and 22 ± 11 months for the HIV-positive cohort and HIV-positive controls, respectively. Three or more elevated readings occurred in 74% of the cohort and in 48% of the HIV-positive controls (P = 0.01) and accounted for 38 ± 25% versus 22 ± 26% (P = 0.01) of the total readings, respectively. The average of the three highest systolic readings (153 ± 17 versus 144 ± 15 mmHg;P = 0.01) and diastolic readings (92 ± 10 versus 87 ± 9 mmHg;P = 0.01) was greater for the cohort than for the HIV-positive controls. Family history of hypertension was more common in the cohort than in the controls but accounted for only 13% of the log odds ratio value for elevated blood pressure in the cohort. Systolic blood pressure was correlated with waist-to-hip ratios in the cohort (r = 0.45;P = 0.003) but not in the HIV controls (r = 0.06;P = 0.68) and tended to be related to fasting triglycerides (r = 0.34;P = 0.052) in subjects with HIV.

Conclusions: Elevated blood pressure may be linked to the metabolic disorders occurring in patients with HIV, as in the dysmetabolic syndrome.

© 2001 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.