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Predictors of tuberculosis transmission in prisons: an analysis using conventional and molecular methods

March, Francescaa,b; Coll, Perea,b,c; Guerrero, Rafael A.b,d; Busquets, Estherd; Caylà, Joan A.b,e; Prats, Guillema,c

Epidemiology & Social

Objective: To determine the tuberculosis (TB) transmission patterns within the prison system in Catalonia, conventional epidemiological techniques were combined with DNA fingerprinting of Mycobacterium tuberculosis.

Methods: IS 6110- and polymorphic GC-rich repeat sequence (PGRS)-based restriction fragment length polymorphism (RFLP) were combined with epidemiological studies to assess the relatedness of isolates from all patients with confirmed TB at five prisons in the province of Barcelona (Catalonia, Spain), between 1 July 1994 and 31 December 1996. Risk factors for transmission were analysed to a logistic regression. The extent of drug-resistant TB was also assessed.

Results: The incidence of TB during the study period was 2775 cases per 100 000 inmate years. Of the 247 culture-positive cases, 126 (51%) appeared to have active TB as a result of recent transmission. Using conventional epidemiological methods, 14 active chains of transmission were identified in prison involving 65 isolates (52% of clustered patients). A lengthy history of imprisonment [odds ratio (OR) 2.8, 95% confidence interval (CI) 1.52–5.11] and pulmonary TB (OR 2.36, 95% CI 1.17–4.75) were independently associated with clustering. Low rates of both initial (2.9%) and acquired drug resistance (5.8%) were identified and there was no evidence of the transmission of drug-resistant TB.

Conclusion: In the prison system studied, the recent transmission of TB contributes substantially to the overall incidence of the disease. Both lengthy incarcerations and delays in identifying inmates with pulmonary symptoms play a key role in this recent transmission. Directly observed therapy (DOT) is a critical control strategy for reducing the emergence of drug resistance and for avoiding the transmission of resistant organisms.

From the aDepartment of Microbiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; bTuberculosis Investigation Unit of Barcelona, Barcelona, Spain; cDepartment of Genetics and Microbiology, Universitat Autònoma de Barcelona, Barcelona, Spain; dHealth Program, Department of Justice of Catalonia, Barcelona, Spain; eEpidemiology Service, Municipal Institute of Health, Barcelona, Spain; fMedical Services, Penitentiary Centers, Barcelona, Spain; gMedical Service, Hospital Penitentiary Center, Barcelona, Spain; hTuberculosis Program, Department of Health of Catalonia, Barcelona, Spain; and iGeneral Lab Laboratory, Barcelona, Spain.

Xavier Garrigaab, Antonio Da Silvaf, Nuria Fauriaf, M. Jesus Lealf, Enric Mercadéf, Cristina Nietof, N. Teixidóf, Inmaculada Vallsf, Josep Gualg, José Alcaideh, Gisela Schmidtg and Nuria Miserachsi

Sponsorship: This work was supported by a grant from the Fondo de Investigación Sanitaria (97-0041).

Correspondence to: Pere Coll, Servei de Microbiologia, Hospital Santa Creu i Sant Pau, Avenida Sant Antoni Maria Claret 167, 08025 Barcelona, Spain. Tel: +34 93 291 90 71; e-mail: pcoll@santpau.es

Received: 10 December 1999; accepted: 22 December 1999.

© 2000 Lippincott Williams & Wilkins, Inc.