Skip Navigation LinksHome > May 1994 - Volume 8 - Issue 5 > Mortality in HIV-1-seropositive women, their spouses and the...
AIDS:
Original Article: PDF Only

Mortality in HIV-1-seropositive women, their spouses and their newly born children during 36 months of follow-up in Kinshasa, Zaire.

Ryder, Robert W.; Nsuami, Malanda; Nsa, Wato; Kamenga, Munkolenkole; Badi, Nsanga; Utshudi, Mulenda; Heyward, William L.

Collapse Box

Abstract

Objective: To calculate 3-year mortality rates in HIV-1-seropositive and HIV-1-seronegative mothers, their newborn children and the fathers of these children.

Design: Longitudinal cohort study of HIV-1-seropositive, age and parity-matched HIV-1-seronegative pregnant women, their newborn babies and the fathers of these children.

Setting: Obstetric ward and follow-up clinic at a large municipal hospital in Kinshasa, Zaire.

Participants: A total of 335 newborn children and their 327 HIV-1-seropositive mothers and 341 newborn children and their 337 HIV-1-seronegative mothers and the fathers of these children.

Main outcome measures: Rates of vertical HIV-1 transmission and maternal, paternal and early childhood mortality.

Results: The lower and upper bounds of vertical transmission were 27 and 50%, respectively. The 3-year mortality rate was 44% in children with vertically acquired HIV-1 infection, 25% in children with HIV-1-seropositive mothers and indeterminant HIV-1 infection status, and 6% in uninfected children with HIV-1-seronegative mothers. HIV-1-seropositive women who transmitted HIV-1 infection to their most recently born child had lost a greater number of previously born children (mean, 1.5 versus 0.5; P< 0.05), were more likely to have had AIDS at delivery (25 versus 12%; P<0.01) and were more likely to die during follow-up (22 versus 9%; P<0.01) than HIV-1-seropositive women who did not transmit HIV-1 infection to their newborn child. Twenty-five out of 239 (10.4%) fathers of children with HIV-1-seropositive mothers, not lost to follow-up, died compared with three out of 310 (1%) fathers of children with HIV-1-seronegative mothers (P<0.01).

Conclusions: Families in Kinshasa, Zaire, in which the mother was HIV-1-sero-positive experienced a five to 10-fold higher maternal, paternal and early childhood mortality rate than families in which the mother was HIV-1 -seronegative.

(C) Lippincott-Raven Publishers.

Login

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.