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Chismark, Elisabeth PhD, RN; Evans, Dian Dowling PhD, FNP-BC
Section Editor(s): Howard, Patricia Kunz PhD, RN, CEN, CPEN, NE-BC, FAEN; Shapiro, Susan E. PhD, RN
Abstract: A recent clinical research study with a case study approach is used to illustrate the importance of translational research in the role of the advanced practice nurse. The case study module used in this column is “Adverse Drug Events in the Emergency Department: Why Genetics Matters in Practice.” The study results showed that patients taking multiple drugs metabolized through the cytochrome P450 enzyme system had a higher prevalence of drug–drug exposure. These drug–drug exposures may lead to potentially serious drug–drug interactions. The implications and clinical relevance of these findings for advance practice nurses are discussed.
© 2012 Lippincott Williams & Wilkins, Inc.
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chronic low back pain, CYP450, drug-drug interactions, polypharmacy
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