Skip Navigation LinksHome > August 2014 - Volume 287 - Issue 1 > Management of pain during injection of propofol
Text sizing:
Adverse Drug Reaction Bulletin:
doi: 10.1097/FAD.0000000000000005
Original Article

Management of pain during injection of propofol

Aronson, Jeffrey K.

Collapse Box


Summary: The results of this narrative review and published systematic reviews suggest that to reduce the risk of pain during injection with propofol one should use a lipid emulsion of propofol, injected into a large vein, preceded by lidocaine 0.5 mg/kg with venous compression for 30–120 s. The addition of other compounds can also be recommended, and ketamine 0.4 mg/kg (adult dose) may be the additional drug of choice, particularly because the combination of ketamine and propofol (ketofol) has added therapeutic benefits. In children Emla cream is an option, but to be effective it must be applied about 4 h before propofol is injected.

© 2014 Lippincott Williams & Wilkins


Article Tools


Article Level Metrics