Emergency situations arise in health care every day. High-risk environments such as Neonatal Intensive Care Units and labor and delivery units are more susceptible to such emergencies. Occasionally, newborns require assistance with their breathing in the delivery room, while others demand intensive resuscitation including intubation and chest compressions. Delivering resuscitative efforts can be difficult when the team trains in separate venues. This article will discuss the importance of multidisciplinary high-fidelity simulation training as an effective tool in the development and maintenance of resuscitation expertise across disciplines, the history of simulation, simulation legislation, and the evidence behind simulation and explore the art and utilization of medical simulation in a multidisciplinary setting.