A model of clinical practice involving neonatal nurse practitioners (NNP) and neonatologists is presented through the application of collaboration theory. This strategy has been used in business and other applications. In this article, the terms and principles of the model will be explained. The relevant features will be identified, including interdependence, communication, strategic negotiation, independent billing, NNP licensure support, semiformal systems, and radical tailorability. Recommendations for structure and components to ensure safe practice involving the unique contributions of the NNP will be highlighted. An example of such a successful practice will be described.