Oral cancers represent about 3% of all the malignancies in people, and 90% of those are squamous cell carcinomas. The strong association between oral cancer and the use of tobacco and alcohol were well established. There are also some suspects about a correlation between drug smoke and oral cancer. We report 5 cases of young people (3 males, 2 females) developing an erythroplastic lesion on a history of drug smoke.