Editor-in-Chief: L. Bruce Gladden, PhD, FACSM
ISSN: 0195-9131
Online ISSN: 1530-0315
Frequency: 12 issues / year
Ranking: 6/81 in Sports Sciences
Impact Factor: 3.983
News & Views from the Editor-in-Chief

There are several studies that I wish to accentuate in this month's MSSE®. In the first study, Schmitt et al. examined the effect of exposure in utero to a common environmental toxicant, benzyl butyl phthalate, on physical activity in both male and female mice. As a result of the exposure, there were significant decreases in voluntary daily distance running, primarily as a consequence of decreased duration of daily activity, in both male and female offspring. Associated with these decreases in activity were significant alterations in sex hormone parameters. These findings are novel because this is the first time that low physical activity levels have been linked to an environmental toxicant exposure in utero. This study introduces new concepts in thinking about how environmental exposures can directly impact subsequent exercise behavior.

In another highlight, Baker and Parise investigated the ability of skeletal muscle to produce erythropoietin in response to hypoxia. That the body can respond to hypoxia in ways other than kidney-mediated erythropoietin expression is well known. The brain, liver, and bone marrow have all been shown to express erythropoietin, and in some cases, increase its expression when challenged by insults such as nephrectomy. This study demonstrated that erythropoietin is also expressed by skeletal muscle and that its expression is regulated by muscle hypoxia. This is especially interesting, considering that exercising skeletal muscles are known to experience a decrease in intracellular partial pressure of oxygen (iPO2).

Finally, please check out the Commentary by Katzmarzyk. He discusses two papers in this month's MSSE® that focus on the topic of physical activity, sedentary behavior, and mortality using data from the U.S. National Health and Nutrition Examination survey (NHANES). Both studies report that replacing sedentary time with light activity was associated with a lower risk of mortality, and that replacing sedentary time with moderate to vigorous activity was associated with an even greater improvement in mortality risk. Katzmarzyk uses these consistent findings to emphasize the critical importance of reproducibility in scientific studies.​


L. Bruce Gladden


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