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Effects of an Injected Placebo on Endurance Running Performance


Medicine & Science in Sports & Exercise: August 2015 - Volume 47 - Issue 8 - p 1672–1681
doi: 10.1249/MSS.0000000000000584
Applied Sciences

Purpose This study aims to quantify the magnitude of the placebo effect of an injected placebo (“OxyRBX”) purporting to have effects similar to those of recombinant human erythropoietin on endurance running performance in “real-world” field-based head-to-head competition settings.

Methods Fifteen endurance-trained club-level men (mean ± SD: age, 27.5 ± 6.8 yr; body mass index, 22.9 ± 2.0 kg·m−2) with 10-km personal-best record times of 39.3 ± 4.4 min completed a randomized cross-over study of 3-km races before and after 7-d “control” and “placebo” phases. During the placebo phase, participants self-administered subcutaneous saline injections daily, believing it to be OxyRBX, with no intervention during the control phase. At the start and end of each 7-d phase, 3-km running performance was assessed. Qualitative assessments of participants’ perceptions and experiences were recorded throughout and during semistructured interviews on completion.

Results Race time improved significantly more in response to placebo intervention (9.73 ± 1.96 s faster, P = 0.0005) than in response to control (1.82 ± 1.94 s faster, P = 0.41; P interaction = 0.02). In response to placebo, participants reported reductions in physical effort, increased potential motivation, and improved recovery. Beliefs and congruence between positive expectations of the effects of placebo and perceptions of physical change during training also appeared to impact on competitive performance.

Conclusions Compared to control, the injected placebo improved 3-km race time by 1.2%. This change is of clear sporting relevance but is smaller than the performance improvement elicited by recombinant human erythropoietin administration. Qualitative data suggest that placebo may have improved performance by both reducing perception of effort and increasing potential motivation, in accord with the psychobiological model for exercise performance, and that cognitive and noncognitive processes appear to have influenced placebo response.

1Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, UNITED KINGDOM; and 2Institute of Health and Wellbeing, College of Social Sciences, University of Glasgow, Glasgow, UNITED KINGDOM

Address for correspondence: Jason M.R. Gill, Ph.D. BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom; E-mail:

Submitted for publication June 2014.

Accepted for publication November 2014.

© 2015 American College of Sports Medicine