Decline in Cardiorespiratory Fitness and Odds of Incident Sleep Complaints

DISHMAN, RODNEY K.1; SUI, XUEMEI2; CHURCH, TIMOTHY S.3; KLINE, CHRISTOPHER E.4; YOUNGSTEDT, SHAWN D.5; BLAIR, STEVEN N.2,6

Medicine & Science in Sports & Exercise: May 2015 - Volume 47 - Issue 5 - p 960–966
doi: 10.1249/MSS.0000000000000506
Epidemiology

Purpose: To examine longitudinal change in cardiorespiratory fitness and odds of incident sleep problems.

Methods: A cohort of 7368 men and 1155 women, age 20–85 yr, was recruited from the Aerobics Center Longitudinal Study. The cohort did not complain of sleep problems, depression, or anxiety at their first clinic visit. Cardiorespiratory fitness assessed at four clinic visits between 1971 and 2006, each separated by an average of 2–3 yr, was used as a proxy measure of cumulative physical activity exposure. Sleep complaints were made to a physician during follow-up.

Results: Across visits, there were 784 incident cases of sleep complaints in men and 207 cases in women. After adjusting for age, time between visits, body mass index, smoking, alcohol use, chronic medical conditions, complaints of depression or anxiety at each visit, and fitness at visit 1, each minute of decline in treadmill endurance (i.e., a decline in cardiorespiratory fitness of approximately 0.5 MET) between the ages of 51 and 56 yr increased the odds of incident sleep complaints by 1.7% (range = 1.0%–2.4%) in men and by 1.3% (range = 0.0%–2.8%) in women. Odds were ∼8% higher per minute decline in people with sleep complaints at visits 2 and 3.

Conclusions: The results indicate that maintenance of cardiorespiratory fitness during middle age, when decline in fitness typically accelerates and risk of sleep problems is elevated, helps protect against the onset of sleep complaints made to a physician.

1Department of Kinesiology, University of Georgia, Athens, GA; 2Department of Exercise Science, University of South Carolina, Columbia, SC; 3Pennington Biomedical Research Center, Baton Rouge, LA; 4Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA; 5College of Nursing and Health Innovation and School of Nutrition and Health Promotion, Arizona State University, Phoenix, AZ; 6Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC

Address for correspondence: Rodney K. Dishman, Ph.D., Department of Kinesiology, University of Georgia, Ramsey Student Center, 330 River Road, Athens, GA 30602-6554; E-mail: rdishman@uga.edu.

Submitted for publication July 2014.

Accepted for publication August 2014.

Article Outline

Poor sleep is recognized as a public health burden (17). Several medical conditions and chronic diseases (e.g., coronary heart disease, hypertension, obesity, diabetes, and metabolic syndrome) are associated with poor sleep, which also contributes to emotional distress and impairment of daytime function. Approximately 17%–24% of middle-age men and women in the United States report trouble falling or staying asleep, or sleeping too much, during the past 2 wk (14). About half of the people who seek treatment for poor sleep will receive a drug prescription, usually a hypnotic, anxiolytic benzodiazepine, or a serotonergic antidepressant (35), that will have varying efficacy and often uncertain safety with long-term use (7,25,28). Many people who do not seek treatment purchase over-the-counter sleep aids or use alcohol to get to sleep at night, which then disrupts sleep during the night (33). The cumulative evidence suggests that regular exercise may compare favorably with other behavioral options (7) for the successful management of sleep disturbance.

Randomized controlled trials of exercise training have shown improvements in ratings of sleep quality in middle-age or older healthy adults (19,20), postmenopausal women (24), and older adults diagnosed with depression (37) or primary insomnia (34); better daytime functioning in patients with sleep apnea (22); and favorable changes in polysomnographic measures of sleep disturbance, as well as ratings of sleep quality, in a nonclinical sample of adults with mild-to-moderate sleep complaints (21).

In contrast to studies of whether exercise improves sleep in people with sleep problems, much less research has focused on whether regular physical activity protects against the onset of sleep problems. In one study, older adults who reported frequent physical activity had a lower incidence of insomnia symptoms for 3 yr compared to their sedentary peers (16). In another recent study, midlife women who consistently reported high levels of recreational physical activity during a 5- to 6-yr span had significantly better sleep quality, sleep continuity, and sleep depth via self-report and polysomnographic assessments compared to their inactive counterparts (23). However, in both of these prospective studies, physical activity was limited to self-report. Moreover, other epidemiological studies reporting an association between physical activity and lower odds of sleep complaints used cross-sectional designs or also relied on self-reports of physical activity and classifications of people into activity groups that were not equivalent across studies (30,39). None concurrently assessed objectively measured change in physical activity exposure, sequential measures of outcome, and discounted residual confounding by fluctuating traits common to physical inactivity and risk of sleep disturbance, including psychiatric comorbidities such as depression and anxiety (36).

Cardiorespiratory fitness (CRF) provides an objective, surrogate measure of change in habitual physical activity exposure. The decline in CRF seen in healthy adults age 40–60 yr, when problems of sleep duration and poor quality are elevated (9,14), is best explained by reduced moderate-to-vigorous physical activity, after accounting for age, body mass index (BMI), and smoking (18). In a previous cross-sectional analysis of 2033 women and 1840 men from the Nord-Trøndelag Health Study, there was an inverse relation between CRF and insomnia symptoms that was independent of age, sex, BMI, cardiovascular risk factors, alcohol use, smoking, and symptoms of depression or anxiety (38). To extend those temporally uncertain findings to a prospective analysis of changing exposure, we hypothesized that steeper declines in CRF among men and women from the Aerobics Center Longitudinal Study (ACLS) cohort would be associated with higher odds of incident sleep complaints made to a physician.

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METHODS

Study Population

The ACLS is a prospective epidemiological study investigating health outcomes associated with physical activity and CRF at the Cooper Clinic, Dallas, TX (5). Participants elected to come to the clinic for periodic preventive medical examinations and for counseling regarding health and lifestyle behaviors, including diet and physical activity. The clinic broadly markets its services via mass media and among occupational groups and serves patients from all 50 states. Many participants were sent by their employer, some were referred by their physicians, and others were self-referred. At the time of their first clinic examination, the ACLS was described to patients who then provided written informed consent (nearly 100% of patients examined) for enrollment in the follow-up longitudinal study. The study protocol was approved annually by the Cooper Institute’s Institutional Review Board.

All ACLS participants received comprehensive preventive medical examinations and maximal graded treadmill exercise tests. Between 1971 and 2006, 9503 participants age 20–85 yr (14% of the enrolled population) without complaints of sleep problems, depression, and anxiety at their first clinic visit received at least four comprehensive medical examinations and maximal graded treadmill exercise tests at routine clinic visits. Participants were excluded from analysis if they did not achieve at least 85% of age-predicted maximum HR during the treadmill test (n = 289) or had missing data on any covariate other than BMI (n = 691). Thus, 7368 men and 1155 women were included for analysis. The median (lower to upper quartile range) of the duration between visits 1 and 2, between visits 2 and 3, and between visits 3 and 4 was 1.13 (1.0–2.1), 1.19 (1.0–2.2), and 1.36 (1.0–2.6) yr, respectively. Most participants were non-Hispanic whites, relatively well educated, and from middle and upper socioeconomic strata.

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Measures

Cardiorespiratory fitness

CRF was defined as the total time of a symptom-limited maximal treadmill exercise test, using a modified Balke protocol. The treadmill speed was 88 m⋅min−1 for the first 25 min. The grade was 0% for the first minute, 2% for the second minute, and then increased 1% each subsequent minute until 25 min had elapsed. After 25 min, the grade remained constant while the speed increased by 5.4 m⋅min−1 until test termination. Patients were encouraged to give a maximal effort, and the test endpoint was volitional exhaustion or termination by the physician for medical reasons. The mean ± SD percentage of age-predicted maximum HR achieved during exercise was 101.5% ± 6.6%. The total time of the test using this protocol correlates highly with measured maximal oxygen uptake in both men (r = 0.92) (31) and women (r = 0.94) (32). Thus, CRF in this study is analogous to the maximal aerobic power defined as METs (1 MET = 3.5 mL O2 uptake⋅kg body weight⋅min−1) when estimated from the final treadmill speed and grade (2). Each minute of maximal treadmill test time reported here predicted 0.49 maximal METs (SEE = 0.27, r = 0.993) for men and 0.46 maximal METs (SEE = 0.15, r = 0.997) for women. The examination included measurement of ECG during rest and exercise. Abnormal exercise ECG responses were broadly defined as rhythm and conduction disturbances or ischemic ST-T wave abnormalities. Trained laboratory technicians, with physician supervision, administered the exercise tests and other procedures according to a standardized manual of operations. At visit 1, maximum HR (mean ± SD) was 175 ± 13 bpm for women and 176 ± 14 bpm for men. Maximum HR at subsequent visits did not differ (P > 0.10) between incident cases of sleep complaints and noncases at subsequent visits.

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Sleep complaints

Sleep complaints were obtained by the medical staff from archived physician charts after following up for patients’ responses on a standardized medical history questionnaire that asked patients to indicate (yes or no) “whether you have ever had a significant problem with any of the symptoms or conditions listed below: difficulty sleeping” and whether difficulty sleeping was a current problem (“Is this still a problem?”). Complaints of depression and anxiety symptoms were assessed the same way.

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Other measures

Height and weight were measured on a standard physician’s balance beam scale and stadiometer. BMI was computed as weight (kg)/height (m)2. Random missing BMI observations (because of manual recording omissions of either height or weight) were 13% of all observations and were replaced by the mean of 10 imputations using a maximum likelihood estimator (29). Resting blood pressure was measured using standard auscultation methods after a brief period of quiet sitting. Blood chemistry was analyzed for lipids and glucose using standardized automated bioassays. Hyperlipidemia was defined as fasting total cholesterol ≥6.2 mmol·L−1 (240 mg·dL−1) or triglyceride ≥2.26 mmol·L−1 (200 mg·dL−1). Individuals who reported a history of physician-diagnosed hypertension or who had blood pressure ≥140/90 mm Hg at the examination were classified as having hypertension. Diabetes was defined as a fasting glucose level ≥7.0 mmol·L−1 (126 mg·dL−1), physician diagnosis, or treatment with insulin. Information on smoking habits (current smoker or not), alcohol intake (drinks per week), and other medical conditions (yes or no) was obtained from a standardized medical history questionnaire. The number of medical conditions was the sum of the seven medical conditions (heart attack, stroke, cancer, diabetes, hypertension, hyperlipidemia, and abnormal resting or exercising ECG).

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Statistical Analyses

Latent transition and class analysis

Participants in the cohort were classified as incident cases and noncases at a subsequent clinic visit using latent transition analysis (LTA) on observed cases and noncases performed by Mplus 7.11 (29). LTA provided Bayesian probability estimates of people being classified as having a sleep complaint or not at visits 3 and 4 given their sleep status at preceding visits 2 and 3. Model fit was tested using a robust maximum likelihood ratio test. The number of classes for incident cases between visits 2 and 4 (i.e., patterns of change) was tested by a significant chi-square change (χ2 Δ) estimated by a bootstrapped likelihood ratio test.

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Latent growth modeling

Trajectories of change in treadmill test duration in minutes were estimated using latent growth modeling (LGM) (6) in Mplus 7.11 after multivariate adjustment of treadmill time for between-participant differences in the covariates measured at each visit (simultaneous adjustment of the time-varying covariates in LGM would not converge because of low within-participant variation in the covariates). The following covariates were included in the model: age at visit 1, time between visits, BMI, smoking (yes/no), alcohol use, number of medical conditions, and complaints of depression or anxiety. The change latent variable was modeled twice: first using just a linear change function and second using both linear and quadratic change functions. Robust maximum likelihood parameters and their standard errors were estimated for initial status (i.e., mean at baseline), change (i.e., slope of differences across the four clinic visits), and the variances (i.e., interindividual differences) of initial status and change.

Baseline status and change in CRF were compared between the two classes (i.e., cumulative incident cases vs noncases) using χ2 difference tests (χ2 Δ) between a freely estimated baseline model and a nested model in which parameters were constrained to be equal between the groups. Model fit was evaluated with multiple indices, including the comparative fit index, Tucker Lewis index, the root mean square error of approximation, and standardized root mean square residual (15).

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Logistic regression analysis

Logistic regression analysis using maximum likelihood estimation was performed in SPSS 21.0 to determine the odds that initial values and change functions (i.e., orthogonal contrasts for linear or quadratic trends) identified by the LGM for adjusted CRF across visits could accurately predict cases of incident sleep complaints (i.e., cumulative cases and noncases defined the binary dependent variable). The group that never complained of sleep problems (i.e., noncases) was the reference for all logistic odds ratios (OR). Statistical significance of likelihood ratios and goodness of model fit were tested by χ2 tests. Sensitivity analysis tested the model while excluding first incidence cases at visits 2 and 3 to help rule out a selection bias of early sleep problems preceding the decline in fitness. Similarly, the decline in CRF was compared between the latent classes of cumulative cases and noncases to estimate the decline in CRF among the patients most likely to have sleep complaints during visits 2–4.

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RESULTS

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Latent transition and class analysis

Prevalence of sleep complaints was 3.4%, 5.3%, and 7.2% of the cohort of men and 5.7%, 8.3%, and 12.4% of the cohort of women at Visits 2–4 (Table 1). There were 251, 389, and 532 first-incident cases of sleep complaints at visits 2–4 in men and 66, 96, and 143 first-incident cases in at visits 2–4 in women. Table 2 shows that, over all three follow-up visits, there were 784 incident cases in men and 207 in women. Cumulative incident rates were 10.6% in men and 17.9% in women (Table 2). Fit of the LTA model was good for men (χ246 = 50.7, P = 0.293) and women (χ246 = 10.0, P = 1.00). Probabilities of incident cases at visits 3 and 4 were 3.6% and 4.5% in men and 6.0% and 7.8% in women. Conversely, probabilities that people who had sleep complaints at the preceding visit but did not complain of sleep problems at the next visit were 46.6% and 43.7% in men and 53% and 37.5% in women, respectively. The best fitting models indicated two classes of cases between visits 2 and 4 for both men (294 cases at two or three of the visits and 7074 noncases; χ2Δ4 = 1334.4, P < 0.001) and women (74 cases at two or three of the visits and 1081 noncases; χ2Δ4 = 243.6, P < 0.001). Three class models were not supported (P > 0.50).

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Latent growth models

Figures 1 and 2 show the initial status and growth trajectories of CRF in men and women, respectively, according to cumulative incident cases of sleep complaints and noncases. Both linear and quadratic trajectories differed between cases and noncases in men (χ2Δ3 =32.9, P < 0.001), whereas the linear trajectory differed (χ2Δ1 = 3.8, P < 0.05), but the quadratic trajectory did not differ (χ2Δ1 = 2.3, P = 0.13) between cases and noncases in women. In men, incident cases had a linear decline (−0.347 min, 95% confidence interval [CI] = −0.588 to −0.106) from their initial level of CRF (19.47 min, 95% CI = 19.20 to 19.74), followed by a smaller quadratic decline (−0.09 min, 95% CI = −0.16 to −0.02), whereas noncases had a linear increase (0.310 min, 95% CI = 0.23 to 0.39) from their initial level (19.12 min, 95% CI = 19.03 to 19.21), followed by a larger quadratic decline (−0.223 min, 95% CI = −0.24 to −0.20). In women, incident cases had a nonsignificant linear change (−0.020 min, 95% CI = −0.45 to 0.41) and a quadratic decline (−0.143 min, 95% CI = −0.27 to −0.02) from their initial level of CRF (14.71 min, 95% CI = 14.22 to 15.20), whereas noncases had a linear increase (0.450 min, 95% CI = 0.246 to 0.654) followed by a similar quadratic decline (−0.241 min, 95% CI = −0.298 to −0.184) from their initial level (14.35 min, 95% CI = 14.11 to 14.59).

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Logistic regression analysis

The logistic model of observed cases had good fit for men (linear change: χ22 = 30.3, P < 0.001; goodness of fit: χ27365 = 7380.6, P = 0.447; Hosmer and Lemeshow: χ28 = 8.49, P = 0.387) and women (linear change: χ22 = 5.3, P = 0.07; goodness of fit: χ21152 = 1156.6, P = 0.457; Hosmer and Lemeshow: χ28 = 6.15, P = 0.631). Odds of incident sleep complaints were 1.7% higher for each minute of linear decline in CRF across visits in men (OR = 1.017, 95% CI = 1.010 to 1.024) and 1.3% higher for each minute of linear decline in CRF across visits in women (OR = 1.013, 95% CI = 0.998 to 1.028).

Odds of incident sleep complaints with declining fitness were equally strong in the sensitivity analysis that excluded people with first incidence at visit 2 or visit 3 in men (6584 noncases and 278 first-incident cases at visit 4; linear decline OR = 1.016, 95% CI = 1.006 to 1.027) and women (948 noncases and 76 first-incident cases at visit 4; linear decline OR = 1.021, 95% CI = 0.998 to 1.044).

Similarly, the model of latent classes of cumulative cases had good fit for men (quadratic change: χ21 = 21.6, P < 0.001; goodness of fit: χ27364 = 7405.6, P = 0.364; Hosmer and Lemeshow: χ28 = 11.13, P = 0.194) and women (quadratic change: χ21 = 4.4, P = 0.037; goodness of fit: χ21151 = 1168.6, P = 0.352; Hosmer and Lemeshow: χ28 = 11.74, P = 0.163). Odds of incident sleep complaints were 7.9% higher for each minute of quadratic decline (OR = 1.079, 95% CI = 1.045 to 1.114) in CRF across visits in men and 7.6% higher for each minute of quadratic decline in women (OR = 1.076, 95% CI = 1.004 to 1.154). The greater CRF decline among cases was between visits 2 and 3 in men and between visits 1 and 2 in women.

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DISCUSSION

These prospective results extend previous findings from studies of self-reported physical activity and risk of sleep problems by showing that the odds of incident sleep complaints were increased by 1.7% in men and 1.3% in women for each minute (i.e., about 0.5 MET) of decline in treadmill performance time from the second to the fourth clinic visit (between ages 51 and 56 yr). Although more modest in size than reported previously by observational studies of physical activity (30), these odds are not biased by self-reporting of physical activity. Also, they represent multiple assessments of exposure and sleep complaint outcomes, which had previously been reported only for a cohort of midlife women using a self-report of physical activity (23).

The analysis cannot fully rule out that incident sleep disturbance resulted in physical inactivity and, hence, reduced CRF. There is some evidence for this alternative interpretation (3,12,26). However, that is unlikely here given the higher odds of sleep complaints with declining fitness held in the sensitivity analysis that excluded people with first incidence at visits 2 and 3, supporting that early onset sleep problems did not precede the decline in fitness. Moreover, when latent classes were formed of people most likely to report sleep complaints at two or three of the visits, decline in CRF among cases was greater than among noncases between visits 2 and 3 in men and between visits 1 and 2 in women. Also, the similar maximum HR observed for incident cases and noncases at each visit and the similar treadmill times for cases and noncases at visits 2 and 3 indicate that people were not less able or were not more willing to perform at their maximum level on the treadmill test when they reported sleep problems.

Novel features of the study include the use of CRF as an objective, surrogate measure of cumulative physical activity exposure across time in men and women from the same cohort and repeated assessment of time-varying covariates. There could be residual confounders by traits common to both physical inactivity and proneness to sleep problems. However, this is the first prospective report of physical activity or fitness and incident sleep complaints to sequentially assess and control for time-varying complaints of anxiety or depression problems, which are comorbid with sleep complaints in middle-age US adults (36).

A weakness of the study is the quantification of sleep complaints made to a physician without elaboration of the type (e.g., restless legs, difficulty initiating or maintaining sleep, snoring, sleep apnea) and/or severity of the underlying sleep problem (1,10). Nonetheless, incident cases of a sleep complaint made to a physician have clinical relevance for public health (17). National US survey reports of similarly nonspecific sleep disturbances (13) have been associated with increased odds of obesity, diabetes, and coronary heart disease, which were adjusted for here. Moreover, the medical screening question we used asked patients whether they had a problem with sleep, which has good discriminant validity to detect symptom levels of low severity when compared with other single-item indicators of self-reported sleep disturbance (8). Thus, we believe our findings add new information on the modifying effect of CRF in the epidemiology of sleep, which typically has not distinguished between sleep complaints, sleep disturbance, and insomnia (27).

Information on sleep pharmacotherapy or other medication use, menopausal or pregnancy status, or dietary habits was not sufficient to include these factors in the analysis. Another limitation is that the cohort was predominantly white, relatively healthy and well-educated, and of middle-to-upper socioeconomic class (4). Like other epidemiological cohort studies, there is possible selection bias or lack of representativeness of the study population. However, the homogeneity of the ACLS population sample on sociodemographic factors enhances the internal validity of our findings, which are consistent with lower odds of incident insomnia symptoms in physically active Japanese elders (15) and a positive cross-sectional association between CRF and sleep duration in Hispanic and black youths (11). Incidence rates of sleep complaints in this predominantly middle-age ACLS cohort (nearly 18% in women and 11% in men) were slightly lower than population estimates in US adults 50–60 yr of age (14). Most of the patients here were middle-age (i.e., between 35 and 65 yr old) throughout the period of observation, and fitness was adjusted for age at the initial clinic visit (when average age was 49 yr and the interquartile range spanned from 41 to 56 yr) as well as time between each visit. Hence, the findings should mostly apply to changes across middle-age participants in these cohorts. Nonetheless, the cohorts were not large enough to permit statistically powerful tests of growth models between cases and noncases stratified by age groups, which would be needed to more precisely estimate the modifying effect of fitness on the risk of sleep complaints across age cohorts.

The decline in fitness seen here among noncases (about 6% in men and 4% in women) is consistent with that observed in the total ACLS cohort (18). Among incident cases of sleep complaints, the linear decline across the four visits was approximately 8% in men and women, which approximates an additional loss of 0.5 min of maximal treadmill time, an amount easily retained in most people through regular, moderate-to-vigorous physical activity consistent with current recommendations for health (30). A large randomized trial would be needed to determine how many incident cases of sleep complaints might be prevented by mitigating this decline in fitness.

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CONCLUSIONS

In summary, the results suggest that maintenance of CRF during middle age, when decline in fitness typically accelerates and risk of sleep problems is elevated, helps protect against the onset of sleep complaints made to a physician in both men and women.

This work was supported by the National Institutes of Health (grant numbers AG06945, HL62508, DK088195, and HL095799). C. Kline was supported by NIH research funding grant K23 HL118318. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

The authors thank the Cooper Clinic physicians and technicians for collecting the baseline data and staff at the Cooper Institute for data entry and data management. This work was performed in the University of Georgia.

The authors have no conflicts of interest to declare. The results of the present study do not constitute endorsement by the American College of Sports Medicine.

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Keywords:

EXERCISE CAPACITY; SLEEP; CLINIC COMPLAINTS

© 2015 American College of Sports Medicine