Medicine & Science in Sports & Exercise:
Sedentary Screen Time and Left Ventricular Structure and Function: The CARDIA Study
GIBBS, BETHANY BARONE1; REIS, JARED P.2; SCHELBERT, ERIK B.1; CRAFT, LYNETTE L.3; SIDNEY, STEVE4; LIMA, JOAO5; LEWIS, CORA E.6
1University of Pittsburgh, Pittsburgh, PA; 2National Heart, Lung, and Blood Institute, Bethesda, MD; 3Northwestern University Feinberg School of Medicine, Chicago, IL; 4Kaiser Permanente Division of Research, Oakland, CA; 5Johns Hopkins Institutes of Medicine, Baltimore, MD; and 6University of Alabama at Birmingham, Birmingham, AL
Address for correspondence: Bethany Barone Gibbs, Ph.D., Physical Activity and Weight Management Research Center, University of Pittsburgh, 2100 Wharton Street, Suite 600, Pittsburgh, PA 15203; E-mail: firstname.lastname@example.org.
Submitted for publication April 2013.
Accepted for publication July 2013.
Introduction: Sedentary screen time (watching TV or using a computer) predicts cardiovascular outcomes independently from moderate and vigorous physical activity and could affect left ventricular structure and function through the adverse consequences of sedentary behavior.
Purpose: This study aimed to determine whether sedentary screen time is associated with measures of left ventricular structure and function.
Methods: The Coronary Artery Risk Development in Young Adults Study measured screen time by questionnaire and left ventricular structure and function by echocardiography in 2854 black and white participants, age 43–55 yr, in 2010–2011. Generalized linear models evaluated cross-sectional trends for echocardiography measures across higher categories of screen time and adjusting for demographics, smoking, alcohol, and physical activity. Further models adjusted for potential intermediate factors (blood pressure, antihypertensive medication use, diabetes, and body mass index).
Results: The relationship between screen time and left ventricular mass (LVM) differed in blacks versus whites. Among whites, higher screen time was associated with larger LVM (P < 0.001), after adjustment for height, demographics, and lifestyle variables. Associations between screen time and LVM persisted when adjusting for blood pressure, antihypertensive medication use, and diabetes (P = 0.008) but not with additional adjustment for body mass index (P = 0.503). Similar relationships were observed for screen time with LVM indexed to height2.7, relative wall thickness, and mass-to-volume ratio. Screen time was not associated with left ventricular structure among blacks or left ventricular function in either race group.
Conclusions: Sedentary screen time is associated with greater LVM in white adults, and this relationship was largely explained by higher overall adiposity. The lack of association in blacks supports a potential qualitative difference in the cardiovascular consequences of sedentary screen-based behavior.
Sedentary time has emerged as an independent risk factor for cardiovascular outcomes and mortality, even among individuals who meet recommendations for physical activity (19,34). Thus, being “sedentary” should no longer be considered the opposite of being “active” but rather an additional metric by which to classify an individual’s overall activity pattern. Understanding how sedentary time contributes to cardiovascular disease is an important area in need of more research. Time spent sitting in screen-based activities for entertainment purposes (e.g., television viewing, using a computer or playing sedentary video games) is a particularly relevant target because it is a major contributor to overall sedentary time (2) and is potentially modifiable.
One pathway through which sedentary behavior may contribute to cardiovascular disease is through an impact on the myocardium. Left ventricular structure and function, most notably left ventricular mass (LVM), reflect adaptions to changes in workload and predict cardiovascular events and mortality (14,22,27). LVM associates with various cardiovascular risk factors, including age, body mass index (BMI), blood pressure, physical activity, alcohol intake, and smoking (9,10,12), but the relationship between sedentary time and left ventricular structure and function has not been studied. Although LVM and left ventricular volumes tend to decrease with bed rest or deconditioning (28,33), the chronic consequences of free-living sedentary time, that is, increased obesity or obesity-related comorbidities (16), are generally associated with increased LVM and worse cardiac function (9,10,18). Exercise also increases LVM and volumes, although these changes are considered favorable adaptions to training (5,31,36). Thus, it is unclear whether and in which direction sedentary time would be related to left ventricular structure and function independently of physical activity, obesity, and obesity-related comorbidities.
Furthermore, it may be possible that the relationship between sedentary time and left ventricular structure and function differs between white and black adults. Data from the National Health and Nutrition Examination Survey suggest that sedentary time is associated with cardiovascular risk factors and obesity in whites but not blacks (15). If sedentary time affects left ventricular structure and function through a pathway of adverse effects on obesity and cardiovascular risk factors, a differential effect across races might be expected.
Elucidating the association of sedentary screen time with left ventricular structure and function is of interest in a population-based cohort to inform public health recommendations about screen-based sedentary behavior. The primary objective of the current study was to investigate associations of recreational, sedentary screen time with LVM and other measures of left ventricular structure and function, independent of moderate and vigorous leisure-time physical activity, in the community-based Coronary Artery Risk Development in Young Adults (CARDIA) study. Secondary objectives were to determine whether associations were consistent between white and black adults, and across levels of physical activity.
The CARDIA study enrolled 5115 black and white adults age 18–30 yr in 1985 and 1986 in Birmingham, Alabama; Chicago, Illinois; Minneapolis, Minnesota; and Oakland, California. CARDIA is a longitudinal cohort study of the development and deteminants of cardiovascular disease over time (8). Follow-up examinations of the cohort have been conducted approximately every 2–5 yr, with the most recent examination having occurred in 2010–2011 (year 25). A total of 3499 participants (72% of the surviving CARDIA cohort) participated in the year 25 examination. Of these, 3475 completed an echocardiogram; measures of left ventricular structure and function were available in 3121. We further excluded 90 participants with adjudicated cardiovascular or related end points (myocardial infarction, angina, revascularization procedure, peripheral artery disease, stroke, chronic heart failure, or end-stage renal disease), 83 participants with poor quality images, and 91 participants with missing covariate information. This resulted in a final sample size of 2854. Participants excluded were slightly older, more likely to be men or black, had completed less education, and had higher median sedentary screen time (3.3 h·d−1 in excluded vs 2.9 h·d−1 in included, P < 0.011). Each CARDIA site obtained approval for all study procedures from a local institutional review board and informed consent from each participant before study assessments.
Standardized protocols for data collection were used across study centers. Participants were asked to fast for at least 12 h before each examination and to avoid smoking or engaging in vigorous physical activity for at least 2 h.
Sedentary time was measured for the first time among CARDIA participants at the year 25 examination using a questionnaire adapted from sedentary behavior questionnaires used in children and adolescents (26,29). The questionnaire measured nonwork-related sedentary time with six questions including television viewing, computer use, travelling in a vehicle, doing paperwork, talking on the phone, or other sedentary recreational activities (e.g., reading a book). Participants could choose one of nine potential durations for each of these activities with a minimum of “none” and a maximum of “6 h or more.” Participants reported usual weekday and weekend behavior separately. For the current analysis, sedentary screen time was calculated as a weighted average of reported weekday and weekend time spent watching television or using a computer for nonwork-related activities. Total sedentary time was also calculated as the weighted average over all six nonwork sitting activities assessed. Two studies using comparable questionnaires reported good reliability and fair to good validity, commensurate with other activity questionnaires (24,30).
Echocardiography was performed at all four CARDIA field centers at the year 25 examination using an Artida 2D (Toshiba Medical Systems, Tokyo, Japan) and a previously described protocol (10). Briefly, M-mode echocardiography was used to measure left ventricular dimensions based on the American Society of Echocardiography’s Guidelines (20). LVM was calculated using the Devereux formula (7). Because various allometric scaling exponents have been used to index LVM to height, we used methods described by Chirinos et al. (3) to estimate nonlinear relationships between LVM and height within our study population. The exponent was 0.99 (95% confidence interval = 0.75–1.23) when including gender in the estimation model. This suggests that height should be taken to approximately the first power, which is equivalent to a linear relationship between height and LVM. Moreover, relationships with screen time were similar whether we used LVM adjusted for height as a covariate, LVM indexed to height2.7, or LVM indexed to height1.7. Thus, we report 1) LVM with linear adjustment for height as a covariate based on the mathematical relationship in our study population and 2) LVM indexed to height2.7 (LVMi) for consistency with other CARDIA reports (10). Left ventricular end-diastolic volumes (EDV) and end-systolic volumes (ESV) were acquired from a two-dimensional four-chamber view and were indexed to height. Mass-to-volume ratio was calculated as the ratio of LVM to EDV (g·mL−1). Relative wall thickness was calculated as the sum of the posterior wall and interventricular septal thicknesses divided by the internal left ventricular diameter, with all measures taken at diastole (6). Stroke volume was the difference between ESV and EDV. Ejection fraction was the ratio of stroke volume to EDV. Sonographers at each field center underwent initial, centralized training followed by ongoing quality assurance and control procedures to assess intra- and intersonographer reproducibility. Intraclass correlation coefficients for repeated LVM, EDV, and ejection fraction ranged from 0.6 to 0.9. Scans were read at a centralized reading center. Intraclass correlation coefficients across readers and within readers ranged from 0.6 to 0.9.
Physical activity was assessed using the CARDIA physical activity questionnaire. This modified version of the Minnesota Leisure Time Physical Activity Questionnaire assesses duration and intensity of various nonoccupational activities and uses formulas to calculate moderate and heavy (vigorous) intensity activity in exercise units (EU) (17). As a point of reference, 300 EU corresponds roughly to meeting the U.S. Department of Health and Human Services’ Guidelines for Physical Activity (37) of 150 moderate or 75 vigorous minutes of weekly physical activity. Education (yr), alcohol consumption (mg·d−1), and smoking (never, former, or current) were assessed by questionnaire. Height and weight were measured in light clothing with a stadiometer and balance beam scale, and BMI was calculated as kg·m−2. Diabetes was defined as either the use of diabetes medications or meeting the American Diabetes Association’s diagnostic criteria (HbA1c ≥ 6.5%, fasting glucose ≥ 126 mg·dL−1, or 2-h postload plasma glucose ≥ 200 mg·dL−1) (1). Systolic and diastolic blood pressures (SBP/DBP) were the average of the second and third automated measurements taken after 5 min of quiet sitting (HEM-907XL; Omron Healthcare, Inc., Lake Forest, IL).
Participant characteristics according to sedentary screen time were described using means and percentages as appropriate. Measures of cardiac structure and function are presented as adjusted least squares means with 95% confidence intervals. Generalized linear models evaluated a test for trend across higher levels of sedentary screen time in progressive models with left ventricular structure and function measures as dependent variables. Cut points for sedentary screen time categories were defined a priori to isolate extreme individuals (e.g., <1 h of screen time per day) and to reflect the sedentary time questionnaire which had an upper limit of 6 h·d−1 for any type of sedentary time. We detected a significant interaction between race and sedentary time for LVM (P < 0.001) and thus report results separately by race. No gender interaction was detected for the relationship between sedentary time and LVM (P = 0.184). Initial models adjusted for age, sex, height (LVM model only), center, education, smoking, alcohol consumption, and moderate and vigorous physical activity. Physical activity was included in the initial model because we were interested in determining whether sedentary screen time was associated with cardiac structure and function, independent of leisure-time moderate or vigorous physical activity.
To examine whether the association between sedentary screen time and LVM was consistent across the range of leisure-time activity, we stratified the study population into quartiles of physical activity (separately for whites and blacks) and examined the joint association of sedentary screen time and LVM within quartiles of physical activity. Quartiles had the following ranges for whites (Q1 = 0–179 EU, Q2 = 180–338 EU, Q3 = 339–539 EU, and Q4 = 496–1872 EU) and for blacks (Q1 = 0–92 EU, Q2 = 93–223 EU, Q3 = 224–408 EU, and Q4 = 409–1772 EU). Similarly, we stratified participants by BMI category (normal: BMI < 25.0 kg·m−2; overweight: BMI = 25.0–29.9 kg·m−2; and obese: BMI ≥ 30.0 kg·m−2) and examined joint associations of screen time and LVM, separately among whites and blacks.
For variables with significant relationships in the previously mentioned analyses, further models adjusted for SBP, DBP, use of antihypertensive medications, diabetes, and BMI. These additional adjustment variables could be in the causal pathway between sedentary screen time and cardiac structure and function; we regarded these models as possibly explanatory as opposed to deconfounding. Lastly, we performed two sensitivity analyses: 1) using total sedentary time as the independent variable and 2) excluding participants taking antihypertensive medications because they are known to affect the myocardium.
All analyses were conducted using Stata version 10.1 (2008, StataCorp College Station, TX).
Of the 2854 eligible participants, 1327 (47%) were black. Median sedentary screen time was 2.7 h·d−1 (interquartile range = 1.5–3.6 h·d−1) among whites and 3.9 h·d−1 (interquartile range = 2.3–5.1 h·d−1) among blacks (P < 0.001). Higher screen time was associated with higher BMI and smoking in both whites and blacks, although gradients were steeper in whites (Table 1). White men, those with less education, hypertension, and diabetes, were more likely to report higher levels of sedentary screen time. SBP and DBP were positively associated with sedentary time in white adults only. Alcohol consumption was related to sedentary screen time in blacks.
Association of sedentary screen time with left ventricular structure and function.
Among whites, higher sedentary screen time was associated with higher LVM (P for trend < 0.001), LVMi (P for trend < 0.001), mass-to-volume ratio (P for trend = 0.002), and relative wall thickness (P for trend = 0.049) independent of demographic characteristics, height (LVM only), alcohol, smoking, and moderate and vigorous physical activity (model 1 in Table 2). Other measures (EDV index, ESV index, ejection fraction, and stroke volume) were not associated with sedentary screen time among whites. No associations between sedentary screen time and any measures of left ventricular structure or function were observed in blacks (see Table 3).
Table 2 also displays further adjustment (models 2 and 3) of least square means for LVM, LVMi, mass-to-volume ratio, and relative wall thickness among white adults only. These measures of left ventricular structure each displayed significant associations with sedentary screen time in minimally adjusted models. The associations largely persisted after additional covariate adjustment for use of antihypertensive medication, SBP, DBP, and diabetes (model 2) but became nonsignificant after further adjustment for BMI (model 3).
Joint association of sedentary screen time and physical activity or BMI with LVM.
Figures 1A and B depict the joint association of sedentary screen time category and leisure-time physical activity quartile in whites and blacks, adjusted for age, sex, height, center, education, smoking, and alcohol consumption (model 1 covariates). Among whites, adjusted mean LVM was higher with each higher category of sedentary screen time in each quartile of physical activity, although this trend was only significant for quartiles 2 and 3 (P for trend = 0.021 and 0.010, respectively). Among blacks, no associations were observed between sedentary screen time and LVM within any of the physical activity quartiles. No significant associations were observed across physical activity quartiles within sedentary screen time categories for whites or blacks.
Among BMI categories, screen time was not associated with LVM in whites (Fig. 1C) or blacks (Fig. 1D). However, a similar and strong relationship where LVM was higher in higher BMI categories was observed in both whites and blacks.
Sedentary screen time and total sedentary time were highly correlated (r = 0.78, P < 0.001) with screen time accounting for an average of 47% ± 17% of total sedentary time. Results were similar when we repeated all analyses substituting total sedentary time as the outcome (data not shown). Findings were also similar when we excluded participants who reported using antihypertensive medications (n = 685, 24%).
In this community-based sample of middle-age adults free from overt clinical cardiovascular disease, we found that higher sedentary screen time, independent of moderate and vigorous leisure-time physical activity, was associated with several measures of left ventricular structure in whites but not blacks. These measures of left ventricular structure included higher LVM, LVMi, mass-to-volume ratio, and relative wall thickness. These associations largely persisted after adjustment for potential intermediate comorbidities, but were explained by further adjustment for overall adiposity.
Sedentary screen time, obesity, and left ventricular structure.
To our knowledge, this report is the first investigation of relationships between sedentary time and left ventricular structure and function and gives insight into pathways through which sedentary behavior may affect cardiovascular outcomes and mortality. In exercise training studies, exercise induces favorable adaptations such as increased LVM, EDV, ejection fraction, and stroke volume (5,31). In the Multi-ethnic Study of Atherosclerosis, intentional exercise was associated with increased LVM, EDV, and stroke volume, and these trends were nonlinear with an increased gradient at lower levels of physical activity (36). In fact, changes to left ventricular structure and function have been hypothesized as an additional pathway through which exercise training improves cardiovascular risk beyond traditional risk factors (21,25). On the other hand, bed rest or deconditioning studies, which could be interpreted as extreme exposure to sedentary behavior, induce a decrease in LVM, mean wall thickness, EDV, and stroke volume, presumably as a physiological response to a decreased myocardial load (28,33). We observed a consistent association of higher LVM with higher screen time in whites across the spectrum of physical activity levels, although most strongly in persons just below (Q2) or just above (Q3) leisure-time physical activity recommendations. We did not detect a lower LVMi with higher sedentary screen time in whites or blacks as might have been expected given the effects observed in bed rest studies and a recent study comparing adults with intellectual disabilities to controls (38). It seems likely that a more extreme gradient in sedentary screen time would be needed to observe such trends.
Among whites, our results suggest that sedentary screen time potentially contributes to adverse cardiac remodeling through its association with comorbidities (hypertension and diabetes) and, to a greater extent, overall adiposity. All measures in our study were assessed concurrently, so we are limited in causal inference, but the most plausible interpretation of our findings is that sedentary screen time contributes to obesity and obesity-related comorbidities, which in turn may lead to increased LVM, LVM indexed to height2.7 and volume, and relative wall thickness. This pathway is suggested by the disappearance of an association between screen time and left ventricular structural measures after stratification by BMI (Fig. 1C) or after multivariate adjustment for BMI (Table 2). Further prospective studies are needed to establish the temporal pattern of sedentary screen time, obesity, and left ventricular structure. Despite this, and taken together with the growing evidence that sedentary time is detrimental to health, the public health community should consider the establishment of sedentary screen time recommendations to augment current physical activity recommendations.
We observed no evidence of an association between sedentary screen time and left ventricular structure in blacks. Because the relationships in whites were explained by obesity and comorbidities, we believe this lack of association in blacks likely stems from the lack of association between sedentary screen time and comorbidities (blood pressure and diabetes) and the weaker relationship of sedentary time with BMI among blacks (Table 1). The disconnect between sedentary time and cardiovascular risk factors among blacks, although not physiologically intuitive, is consistent with previous studies (15,23). In the National Health and Nutrition Examination Survey 2003–2006, Healy et al. (15) found that higher accelerometry-derived sedentary time was related to worse cardiovascular risk factors in whites (waist circumference, SBP, HDL cholesterol, insulin, and insulin sensitivity) but was associated with lower waist circumference and was unrelated to other cardiovascular risk factors among blacks. An analysis of 15,349 9th–12th graders from the Youth Risk Behavioral Survey found that more television watching was associated with greater odds of being overweight in whites but not blacks (23). Our findings extend evidence of a race interaction within the relationship between sedentary time and cardiovascular risk to a subclinical marker of cardiovascular disease. In our study, the lack of an association among black adults could be due to a higher amount of sedentary screen time coupled with reduced leisure-time physical activity. These distributional differences, specifically lack of range, could limit the ability to observe effects of sedentary time on left ventricular measures in blacks. Although the source of the interaction, be it differential distributions, unmeasured confounding, genetic, or cultural factors, is unclear, studies investigating the effect of sedentary time on cardiovascular outcomes in blacks is an area in need of further research.
Although our results are strengthened by the sample size, design, and extensive assessments conducted by CARDIA, several limitations of our analysis elicit cautious interpretation of results. First, as previously mentioned, the current study was cross-sectional and thus the temporal sequence of sedentary lifestyle and left ventricular structure and function cannot be established. Second, the small age range (43–55 yr) may limit the generalizability of our results to younger or older adults. Third, sedentary screen time was assessed by self-report, and a review (4) along with two more recent reports (24,30) of the measurement properties of self-reported sedentary time have identified respectable reliability but important limitations in validity. For example, overlapping questions (e.g., a person could be watching television and using a computer simultaneously) could overestimate sedentary time, social desirability bias could underestimate sedentary time, and the best criterion measure, particularly for domain-specific sedentary time, remains unclear. In response to these limitations, we tested for trends across screen-time categories which likely classified most individuals in the extremes and resisted the potential for undue influence by outliers. Similar limitations of self-report apply to the measurement of physical activity (32), which was an important covariate in our analysis. Lastly, measurement by echocardiography, although cost-effective for large epidemiologic studies, has been found to overestimate LVM compared with magnetic resonance imaging (13). However, this limitation is more of a concern for repeated-measures or individual risk stratification (13), and we expect that the associations we observed were, if anything, attenuated as a result of such measurement error. Echocardiography also cannot assess the expansion of the extracellular matrix in the myocardium, which reflects pathologic (vs adaptive) left ventricular hypertrophy (35) is quantifiable by cardiac magnetic resonance imaging, is a potent predictor of mortality (39), and could shed light on the relationships between sedentary time, physical activity, and cardiovascular outcomes. Also, speckle-tracking echocardiography, which measures left ventricular deformation, identifies early cardiac dysfunction, and has been shown to distinguish between pathologic and adaptive left ventricular hypertrophy in exercise studies (11), could be helpful for defining how sedentary behavior affects left ventricular structure and function. Future investigations using these or other more sensitive subclinical measures may yet detect associations between sedentary time and left ventricular function.
Higher sedentary screen time was linked to a larger left ventricle in whites, and this relationship was observed even among individuals meeting or exceeding moderate/vigorous physical activity recommendations. On the other hand, the lack of a relationship between sedentary screen time and left ventricular structure and function observed among black adults in the current study highlights the need for further investigation. Future research should continue to study relationships between sedentary behavior and cardiovascular outcomes using more discriminating measures of cardiac structure and function and with special attention to potential effect modification by race.
This study was supported by the Coordinating Center, University of Alabama at Birmingham (grant no. N01-HC-95095); the Field Center, University of Alabama (grant no. N01-HC-48047); the Field Center and Diet Reading Center, University of Minnesota (grant no. N01-HC-48048); the Northwestern University Field Center (grant no. N01-HC-48049); and the Kaiser Foundation Research Institute (grant no. N01-HC-48050) from the National Heart, Lung, and Blood Institute. The CARDIA ECG Ancillary Study was supported by the National Heart, Lung, and Blood Institute (grant no. R01-HL-086792).
The authors thank Dr. Anderson Armstrong for his invaluable contributions as an external reviewer of this manuscript.
The authors declare no conflict of interest. The results of this study do not constitute endorsement by the American College of Sports Medicine.
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LEFT VENTRICULAR MASS; SEDENTARY TIME; RACE DIFFERENCES; ECHOCARDIOGRAPHY
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