ISBN: 978-1-60327-477-7. Copyright: 2011. Edition: 1st. Editor: George S. Eisenbarth, MD, PhD. Specialties: Immunology, Endocrinology/Metabolic Disease. Publisher: Humana Press, Inc. List Price: $189.00
This book explores in detail the current knowledge of immunoendocrinology, namely endocrine disorders produced by disorders of immune function. It covers basic pathophysiology informed by studies of animal models (where specific animal models are most informative) as well as the predominant current understanding of other related clinical diseases—their pathophysiology, diagnosis, and therapy.
Recognizing a multitude of autoimmune endocrinopathies, the purpose is to explore in detail the current knowledge of immunoendocrinology—the study of endocrine disorders caused by altered immune function.
Endocrinologists with a specific interest in autoimmune endocrinopathies, academic researchers, and physicians (e.g., rheumatologists) who care for patients with autoimmune diseases.
Many of the most important endocrine disorders have an autoimmune etiology. Yet, it is not evident how altered immune function leads to endocrine abnormalities. As such, immunoendocrinology, which seeks to understand factors at the intersection of immunology and endocrinology, is an exciting and growing field. The book starts with a primer on immunoendocrinology and continues with basic concepts in immunology and autoimmunity. Next, a variety of polyglandular autoimmune syndromes are discussed, including APS-1, APS-2, and IPEX syndromes. Chapters on specific disorders follow, ranging from animal models of autoimmune endocrinopathies to discussions of specific disorders such as type 1 diabetes, Addison disease, autoimmune thyroid disease, celiac disease, hypoparathyroidism, and others. Although some important clinical aspects are discussed, the strength of the book is its focus on the underlying pathophysiological mechanisms, autoimmunity, and genetic traits of these disorders. Given the wealth of new data related to type 1 diabetes, approximately half of the book is devoted to this condition and related disorders.
This is a great introduction to the field of immunoendocrinology, particularly for those with previous background in the disorders that are discussed. The chapters are well written and informative. References are pertinent and current. The index is helpful. Illustrations are sufficient in number but are not of superb quality. The chapters are fairly detailed, probably more so than what would be required for the casual reader. The authors are all experts in their respective fields. I strongly recommend this text; it is a worthwhile contribution to this field.
Reviewed by: Ronald Cohen, MD (University of Chicago Medical Center Chicago, IL)