F-23 Free Communication/Poster - Cycling and Running: JUNE 3, 2011 1:00 PM - 6:00 PM: ROOM: Hall B
Massive use of non-steroidal anti-inflammatory drugs (NSAIDs) by athletes has been widely reported in the literature.
PURPOSE: To analyze the effects of prophylactic administration of a single dose of Ibuprofen (1,2g) on the performance, glomerular filtration (GF), serum levels of muscle damage markers, and dehydration in experienced runners submitted to a simulated 10 km race. Desing: Randomized, crossover and double blind trial.
METHODS: Thirteen experienced athletes (31±5 y, 64±7kg, 173±8cm, 4.5±1.2% body fat, maximal oxygen uptake 63.2±5.4 ml·kg-1·min-1) took 2 simulated 10 km competitions (SCs), as we measured glomerular filtration (51Cr-EDTA clearance), creatine kinase ([CK]), myoglobin ([MB]), and hematocrit (Ht), as well as performance in each of the situations (simulated competition with Ibuprofen administration - SCIbu and simulated competition with placebo administration - SCPla). The study was approved by the Ethical Research Committee of the Clínicas Hospital of Porto Alegre.
RESULTS: No significant alteration was detected in [CK] (p=0.89) and [MB] (p=0.17) levels, neither in Ht (p=0.15), in any of the SCs. GF was reduced in both situations (p<0.01), although with no effect potentiated by the NSAID (p=0.17). Performance in the SCIbu was significantly reduced (p=0.021), suggesting a negative effect of PG2α and TXA2 inhibition on oxygen consumption from the reduction in the distribution of volemy.
CONCLUSION: The acute administration of NSAID Ibuprofen does not significantly reduce glomerular filtration in the assessed conditions, but is not effective in reducing skeletal muscle damage resulting from exercise and, contrary to the literature, acts negatively on the performance of conditioned runners.