Effect Of Ibuprofen On Performance, Muscle Damage Markers And Glomerular Filtration During 10 Km Race: 2773: Board #72 June 3 3:30 PM - 5:00 PM

Da Silva, Eduardo R.; Ribeiro, Jorge P.; Luz, Clarice; De Moraes, Ilza V.; Martins, Jocelito B.; De Rose, Eduardo H. FACSM; Kruel, Luiz F.M.

Medicine & Science in Sports & Exercise:
doi: 10.1249/01.MSS.0000402165.48135.f1
F-23 Free Communication/Poster - Cycling and Running: JUNE 3, 2011 1:00 PM - 6:00 PM: ROOM: Hall B
Author Information

1Universidade de Caxias do Sul, Brasil, Porto Alegre, Brazil. 2Hospital de Clínicas de Porto Alegre, Brazil, Porto Alegre, Brazil. 3LabVitrus Laboratory, Porto Alegre, Brazil. 4Laboratório de Pesquisa do Exercício - Federal University of Rio Grande do Sul, Brazil, Porto Alegre, Brazil. 5Medical Committee of the Pan-American Sports Organization, Porto Alegre, Brazil. 6Grupo de Pesquisa em Atividades Aquáticas e Terrestres - Federal University of Rio Grande do Sul, Brazil, Porto Alegre, Brazil.

Email: edurramos@gmail.com

(No relationships reported)

Massive use of non-steroidal anti-inflammatory drugs (NSAIDs) by athletes has been widely reported in the literature.

PURPOSE: To analyze the effects of prophylactic administration of a single dose of Ibuprofen (1,2g) on the performance, glomerular filtration (GF), serum levels of muscle damage markers, and dehydration in experienced runners submitted to a simulated 10 km race. Desing: Randomized, crossover and double blind trial.

METHODS: Thirteen experienced athletes (31±5 y, 64±7kg, 173±8cm, 4.5±1.2% body fat, maximal oxygen uptake 63.2±5.4 ml·kg-1·min-1) took 2 simulated 10 km competitions (SCs), as we measured glomerular filtration (51Cr-EDTA clearance), creatine kinase ([CK]), myoglobin ([MB]), and hematocrit (Ht), as well as performance in each of the situations (simulated competition with Ibuprofen administration - SCIbu and simulated competition with placebo administration - SCPla). The study was approved by the Ethical Research Committee of the Clínicas Hospital of Porto Alegre.

RESULTS: No significant alteration was detected in [CK] (p=0.89) and [MB] (p=0.17) levels, neither in Ht (p=0.15), in any of the SCs. GF was reduced in both situations (p<0.01), although with no effect potentiated by the NSAID (p=0.17). Performance in the SCIbu was significantly reduced (p=0.021), suggesting a negative effect of PG2α and TXA2 inhibition on oxygen consumption from the reduction in the distribution of volemy.

CONCLUSION: The acute administration of NSAID Ibuprofen does not significantly reduce glomerular filtration in the assessed conditions, but is not effective in reducing skeletal muscle damage resulting from exercise and, contrary to the literature, acts negatively on the performance of conditioned runners.

© 2011 American College of Sports Medicine