B-17 Thematic Poster - Nutritional Antioxidants and Oxidative Stress: JUNE 1, 2011 1:00 PM - 3:00 PM: ROOM: 404
Aging and eccentric exercise are associated with muscle inflammation, and aging is also associated with alterations in redox status. Oats contain a unique group of phytochemicals known as avenanthramides (AVA) that have been shown to decrease pro-inflammatory cytokine production and to serve as antioxidants.
PURPOSE: To investigate the effects of dietary AVA supplementation on the inflammatory and oxidative responses to downhill walking in post-menopausal women.
METHODS: Sixteen post-menopausal women aged 50-80 year were randomly assidgned to two groups, eating two 60-g cookies daily made with oat flour (50% by weight) containing either 152 mg AVA/kg (A) or 10.4 mg AVA/kg (C), for 8 wks. Before and after the supplementation period, subjects walked on a treadmill at 2.5 mph, -9% grade for four 15 min bouts with 5 min rest intervals. Blood samples were collected before and 24- and 48-h post exercise.
RESULTS: Plasma interleukin (IL)-1B concentration decreased in A vs. C, at rest and 24-h after exercise. IL-6 concentration was lower in A vs. C 48 h after exercise, and plasma C-reactive protein concentration was lower in A vs. C at 24- and 48-h post exercise following supplementation. Plasma Trolox-equivalent total antioxidant capacity increased following the supplementation period in A but not in C both at rest and after exercise.
CONCLUSIONS: Our data indicate that dietary AVA supplementation may decrease plasma inflammatory cytokine levels and increase antioxidant defense in post-menopausal women.