Moderate Intensity Exercise Training Improves Lipid Profile In Hiv-infected Men.: 2616: Board #10 May 29 2:00 PM - 3:30 PM

Hand, Gregory A. FACSM1; Jaggers, Jason R.1; Lyerly, G. William1; Dudgeon, Wesley D.2; Phillips, Kenneth D.3; Durstine, J. Larry FACSM1; Burgess, Stephanie1

Medicine & Science in Sports & Exercise: May 2009 - Volume 41 - Issue 5 - p 405
doi: 10.1249/01.MSS.0000355781.78336.d4
F-22 Free Communication/Poster - Clinical Exercise Physiology: MAY 29, 2009 1:00 PM - 6:00 PM ROOM: Hall 4F

1University of South Carolina, Columbia, SC. 2The Citadel, Charleston, SC. 3University of Tennesee, Knoxville, TN.

(No relationships reported)

PURPOSE: To determine the effects of a moderate dose of exercise training on blood lipids in HIV-infected men.

METHODS: Sixteen HIV-infected men were recruited for this study and randomized into either an exercise (EX) training group, or control (CON) group who attended the sessions but did not participate in exercise training. The EX subjects participated in a 6 week program of moderate intensity resistance training at 60% of their 3-rep max (approximately 20 min), as well as aerobic exercise for 30 min at 60% of their age predicted heart rate max (twice per week). The CON group received standard care during the same 6 week period and did not increase their activity level. All subjects provided a 12-hour fasting blood draw at pre- and post-treatment.

RESULTS: Results show that at baseline LDL cholesterol was in the "high risk" range for CVD (182±55 mg/dl) and baseline triglyceride was in the "borderline high" range (155±70 mg/dl). Pre- to post-intervention analysis showed a significant reduction in triglyceride level (155±70 to 110±30 mg/dl) and a trend (p=0.07) towards a decrease in LDL cholesterol (182±55 to 171±33 mg/dl). Measurement of occupational and leisure activity showed no change in either group.

CONCLUSIONS: These data show moderate dosage of combined aerobic and resistance training can decrease HIV-associated high levels of circulating triglycerides and cholesterol after only 6 weeks. The results suggest that HIV infection does not reduce the beneficial effects of moderate intensity exercise training on blood lipids, and that training can reduce the risk of CVD in this population.

This project was Supported by the NIH/NCMHD (5P20MD001770-03) and the American College of Sports Medicine.

©2009The American College of Sports Medicine