Enter your Email address:
Wolters Kluwer Health may email you for journal alerts and information, but is committed
to maintaining your privacy and will not share your personal information without
Leithauser, Renate M.1; Roth, Heinz J.2; Beneke, Ralph FACSM1
1Department of Biological Sciences, University of Essex, Colchester, United Kingdom. 2Limbach Laboratories, Heidelberg, Germany.
(No relationships reported)
The prostate-specific antigen (PSA) is a very specific tumor marker used not only in follow-up assessment of prostate cancer patients but also for screening purposes. Usually the total PSA, the free PSA and the percentage of free PSA on total PSA (%fPSA) are examined. Cycle exercise has been discussed as potentially causing unspecific increases in PSA. It remains unclear whether a PSA increase following cycling is due to the sitting on a saddle for a prolonged period of time which may have a similar effect as a prostate gland massage or the exercise itself. Whether running exercise has an effect on PSA concentration has not yet been investigated.
PURPOSE: To analyze the effect of prolonged running exercise on the concentration of total and free PSA as well as %fPSA.
METHODS: Nine healthy male recreational runners (mean ± SD; age 51.7 ± 9.9 yrs, height 1.77 ± 0.08 m, body mass 74.8 ± 6.5 kg) performed a marathon run. Venous blood was taken before the start, after the half-marathon and the marathon distance. Total and free PSA were analyzed (Roche diagnostics) and %fPSA calculated.
RESULTS: Pre-race values of total (1.40 ± 1.22 μg L−1) and free PSA (0.28 ± 0.18 μg L−1) as well as %fPSA (24.04 ± 8.60 %) were well within the reference range for healthy subjects. Total PSA, free PSA and %fPSA remained unchanged (p > 0.05) during (total PSA 1.57 ± 1.46 μg L−1; free PSA 0.32 ± 0.23 μg L−1; %fPSA 24.15 ± 7.98 %) and after the running exercise (total PSA 1.58 ± 1.44 μg L−1; free PSA 0.33 ± 0.23 μg L−1; %fPSA 24.82 ± 9.42 %).
CONCLUSION: Total PSA, free PSA and %fPSA seem to be unaffected by running exercise. In conjunction with divergent findings after prolonged cycling the present results indicate that not only exercise but also the mode of exercise must be considered in PSA interpretation.
Supported by Limbach Laboratories, Heidelberg, Germany.
©2008The American College of Sports Medicine
Colleague's E-mail is Invalid
Your Name: (optional)
Separate multiple e-mails with a (;).
Thought you might appreciate this item(s) I saw at Medicine & Science in Sports & Exercise.
Send a copy to your email
Your message has been successfully sent to your colleague.
Some error has occurred while processing your request. Please try after some time.
An Existing Folder
A New Folder
The item(s) has been successfully added to "".
Login with your LWW Journals username and password.
Username or Email:
Enter and submit the email address you registered with. An email with instructions to reset your password will be sent to that address.
Link to reset your password has been sent to specified email address.
What does "Remember me" mean?
By checking this box, you'll stay logged in until you logout. You'll get easier access to your articles, collections,
media, and all your other content, even if you close your browser or shut down your
To protect your most sensitive data and activities (like changing your password),
we'll ask you to re-enter your password when you access these services.
What if I'm on a computer that I share with others?
If you're using a public computer or you share this computer with others, we recommend
that you uncheck the "Remember me" box.
Save my selection
Article Level Metrics