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Leithauser, Renate M.1; Roth, Heinz J.2; Beneke, Ralph FACSM1
1Department of Biological Sciences, University of Essex, Colchester, United Kingdom. 2Limbach Laboratories, Heidelberg, Germany.
(No relationships reported)
The prostate-specific antigen (PSA) is a very specific tumor marker used not only in follow-up assessment of prostate cancer patients but also for screening purposes. Usually the total PSA, the free PSA and the percentage of free PSA on total PSA (%fPSA) are examined. Cycle exercise has been discussed as potentially causing unspecific increases in PSA. It remains unclear whether a PSA increase following cycling is due to the sitting on a saddle for a prolonged period of time which may have a similar effect as a prostate gland massage or the exercise itself. Whether running exercise has an effect on PSA concentration has not yet been investigated.
PURPOSE: To analyze the effect of prolonged running exercise on the concentration of total and free PSA as well as %fPSA.
METHODS: Nine healthy male recreational runners (mean ± SD; age 51.7 ± 9.9 yrs, height 1.77 ± 0.08 m, body mass 74.8 ± 6.5 kg) performed a marathon run. Venous blood was taken before the start, after the half-marathon and the marathon distance. Total and free PSA were analyzed (Roche diagnostics) and %fPSA calculated.
RESULTS: Pre-race values of total (1.40 ± 1.22 μg L−1) and free PSA (0.28 ± 0.18 μg L−1) as well as %fPSA (24.04 ± 8.60 %) were well within the reference range for healthy subjects. Total PSA, free PSA and %fPSA remained unchanged (p > 0.05) during (total PSA 1.57 ± 1.46 μg L−1; free PSA 0.32 ± 0.23 μg L−1; %fPSA 24.15 ± 7.98 %) and after the running exercise (total PSA 1.58 ± 1.44 μg L−1; free PSA 0.33 ± 0.23 μg L−1; %fPSA 24.82 ± 9.42 %).
CONCLUSION: Total PSA, free PSA and %fPSA seem to be unaffected by running exercise. In conjunction with divergent findings after prolonged cycling the present results indicate that not only exercise but also the mode of exercise must be considered in PSA interpretation.
Supported by Limbach Laboratories, Heidelberg, Germany.
©2008The American College of Sports Medicine
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