Annual Meeting Abstracts: G-27 – Free Communication/Poster: Endocrinology
PURPOSE: Because Breast Cancer (BrCa) survivors are at risk for secondary tumors, they form a high-risk group in whom effects of exercise on risk factors for BrCa can be evaluated, including effects on insulin and growth factors. METHODS: We conducted a 6 month randomized controlled trial in 76 recent BrCa survivors to assess the effects of twice weekly progressive resistance training on insulin, Insulin-like Growth Factor 1 (IGF-1) as well as IGF-2 and associated binding proteins. Randomization was stratified by body fat at baseline. Mean attendance level was 94% over 6 months, with a range of 85 to 109% in the 37 women randomized to treatment. Body composition variables were assessed by DEXA. Insulin was assessed with a radioimmunoassay. Growth factor and binding protein assays were performed using ELISA. Regression models predicting blood assay outcomes from treatment status were adjusted for baseline fat mass, lean mass, and age. RESULTS: are presented in table 1. CONCLUSIONS: Twice weekly progressive resistance training is an exercise regimen that BrCa survivors find behaviorally feasible. The clinical significance of the 2.5% reduction in IGF-2 observed in the treatment group remains to be elucidated, particularly in the absence of changes in IGF-1, insulin, and associated binding proteins. Supported by Susan Komen Foundation BCTR 1011442 and NIH M01-RR00400.