Enter your Email address:
Wolters Kluwer Health may email you for journal alerts and information, but is committed
to maintaining your privacy and will not share your personal information without
Charkoudian, N1; Basu, A1; Joyner, M J.1
1Depts. of Anesthesiology, Endocrinology and General Clinical Research Center, Mayo Clinic, Rochester, MN 55905
Local temperature has an important role in the control of the skin circulation in humans, and can change skin blood flow from zero to maximal levels. Vasodilation to local warming of the skin includes important roles for sensory nerves and nitric oxide. In individuals with type 2 diabetes mellitus (DM), cutaneous vascular function is impaired, but the mechanisms are not well understood.
To test whether local warming vasodilation is altered in type 2 DM, and to test whether hyperglycemia per se has a role in altered local control of skin blood flow in diabetes.
1. We used nonpainful local warming (42°C) of the skin in combination with laser-Doppler measurement of skin blood flow in individuals with type 2 DM and in age-matched controls. 2. In separate studies, we measured responses to similar local warming in healthy individuals during acute hyperglycemia induced by intravenous infusion of glucose with simultaneous insulin, somatostatin, glucagon and growth hormone infusions to keep all other hormones at baseline physiological levels.
Preliminary results indicate diminished vasodilation to nonpainful local warming in patients with type 2 DM compared to controls, including a decrease of ∼20% in both the initial peak (sensory nerve mediated) and final plateau (NO dependent) phases of the response. Acute hyperglycemia in healthy subjects did not alter cutaneous vasodilation to local warming.
Cutaneous vasodilation to nonpainful local warming is impaired in type 2 DM. Although one episode of acute hyperglycemia did not affect this response in healthy subjects, this impairment in patients may be a result of repeated episodes or higher levels of hyperglycemia in the development of the disease. Supported by NIH DK-29953, HL-63328, AR-08610 and GCRC grant RR-00585 (to the Mayo Clinic).
©2003The American College of Sports Medicine
Colleague's E-mail is Invalid
Your Name: (optional)
Separate multiple e-mails with a (;).
Thought you might appreciate this item(s) I saw at Medicine & Science in Sports & Exercise.
Send a copy to your email
Your message has been successfully sent to your colleague.
Some error has occurred while processing your request. Please try after some time.
An Existing Folder
A New Folder
The item(s) has been successfully added to "".
Login with your LWW Journals username and password.
Username or Email:
Enter and submit the email address you registered with. An email with instructions to reset your password will be sent to that address.
Link to reset your password has been sent to specified email address.
What does "Remember me" mean?
By checking this box, you'll stay logged in until you logout. You'll get easier access to your articles, collections,
media, and all your other content, even if you close your browser or shut down your
To protect your most sensitive data and activities (like changing your password),
we'll ask you to re-enter your password when you access these services.
What if I'm on a computer that I share with others?
If you're using a public computer or you share this computer with others, we recommend
that you uncheck the "Remember me" box.
Save my selection
Article Level Metrics