Enter your Email address:
Wolters Kluwer Health may email you for journal alerts and information, but is committed
to maintaining your privacy and will not share your personal information without
Minson, C T.1
1Department of Exercise and Movement Science, University of Oregon, Eugene, OR
Nitric oxide (NO) is known to be a potent vasodilator throughout the circulation and has been shown to have a number of roles in the regulation of vascular tone in humans. During whole body heat stress, an elevation in core body temperature causes a reflex increase in skin blood flow that is partially dependent on NO. However, the exact role of NO in cutaneous active vasodilation is unclear. Animal research suggests that NO may play a “permissive” role in active vasodilation. That is, only a basal level of NO is required to allow full expression of active vasodilation mediated by an unknown neurotransmitter. In humans, we have found NO is not permissive for active vasodilation, but may act in a “synergistic” fashion. In this construct, NO and the unknown neurotransmitter may both directly mediate a portion of active vasodilation, but their combined effect is greater than the sum of their independent actions. This interaction may occur at the nerve where NO pre-junctionally enhances release of the unknown neurotransmitter or at the level of the second messenger systems. Of the main candidates for the putative vasodilator, vasoactive intestinal peptide (VIP) has been found to interact with NO in a synergistic manner in some animal tissues. Along these lines, we recently determined that NO-synthase inhibition blunts the vasodilator response to VIP in human skin; however, it is not yet known whether NO and VIP interact in a synergistic fashion. NO may interact with other neurotransmitters in the skin as well. For example, evidence suggests that NO may interact with various neurotransmitters released during direct heating of the skin, activation of the axon reflexes, pain sensation, and inflammation. Current research is directed towards understanding the complex interactions between NO and vasoactive substances in the regulation of cutaneous vascular tone. Supported by NIH HL70928, AHA 0265260Z
©2003The American College of Sports Medicine
Colleague's E-mail is Invalid
Your Name: (optional)
Separate multiple e-mails with a (;).
Thought you might appreciate this item(s) I saw at Medicine & Science in Sports & Exercise.
Send a copy to your email
Your message has been successfully sent to your colleague.
Some error has occurred while processing your request. Please try after some time.
An Existing Folder
A New Folder
The item(s) has been successfully added to "".
Login with your LWW Journals username and password.
Username or Email:
Enter and submit the email address you registered with. An email with instructions to reset your password will be sent to that address.
Link to reset your password has been sent to specified email address.
What does "Remember me" mean?
By checking this box, you'll stay logged in until you logout. You'll get easier access to your articles, collections,
media, and all your other content, even if you close your browser or shut down your
To protect your most sensitive data and activities (like changing your password),
we'll ask you to re-enter your password when you access these services.
What if I'm on a computer that I share with others?
If you're using a public computer or you share this computer with others, we recommend
that you uncheck the "Remember me" box.
Save my selection
Article Level Metrics