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00005768-201005001-0001700005768_2010_42_6_hastings_distensibility_5miscellaneous< 15_0_1_0 >Medicine & Science in Sports & Exercise© 2010 American College of Sports MedicineVolume 42(5) Supplement 1May 2010p 6Lifelong Exercise Training Demonstrates a Dose Dependent Effect on Left Ventricular Compliance and Distensibility: 603: June 2 11:00 AM - 11:15 AM[A-14 Free Communication/Slide - Cardiac: JUNE 2, 2010 9:30 AM - 11:30 AM: ROOM: 331]Hastings, Jeffrey L.; Bhella, Paul S.; Shibata, Shigeki; Fujimoto, Naoki; Carrick-Ranson, Graeme; Minniefield, Nicole; McLoughlin, James; Boyd, Kara; Palmer, M D.; Levine, Benjamin D. FACSM1The University of Texas Southwestern Medical School, Dallas, TX. 2Institute for Exercise and Environmental Medicine, Dallas, TX.(No disclosure reported)Email: JeffHastings@texashealth.org PURPOSE: Sedentary aging leads to a decrease in left ventricular chamber compliance and distensibility, essentially a stiffening of the heart. Previous data from our lab shows Masters' athletes who train 6-7 sessions per week throughout their adult lives maintain a youthful cardiac elasticity (Circulation. 2004;110:1799-1805). We hypothesized that preservation of compliance during aging may be possible with less rigorous but lifelong training.METHODS: 68 seniors (23 females), aged 69 ± 4 were recruited from: 1) the Aerobics Center Longitudinal Study, a well validated study which has prospectively documented lifelong exercise training patterns in subjects for the past 25 years, 2) regional road-race results and 3) US Masters competitions. Subjects were grouped into quads based on history of exercise training: Quad1 < 2 sessions/wk (n=13); Quad2 = 2 - 3 sessions/wk (n=6); Quad3 = 4 - 5 sessions/wk (n=12); Quad4 = 6 - 7 sessions/wk plus regular competitions (n=18). Testing included maximal exercise for measurement of peak oxygen uptake as well as right heart catheterization and transthoracic echo to define LV pressure-volume curves. PCWP and LVEDV were measured at five cardiac loading conditions; baseline, lower-body negative pressure (-15 and -30 mmHg) and saline infusion (15 and 30 ml/kg).RESULTS: The pressure-volume relationships demostrate an almost doubling of stiffness with healthy sedentary aging compared to the highest fitness group (stiffness coefficient: Quad1=9.5 vs Quad4=5.7). Peak VO2 was progressively higher for each quad in proportion to the amount of lifelong exercise training (Quad1 13.6±1.8 ml/kg/min, Quad2 = 15.9±1.9, Quad3 = 19.8±5.4, Quad4 = 29.4±4.3).CONCLUSIONS: Lifelong exercise training has a dose-dependent effect on left ventricular chamber compliance and distensibility. Based on these findings, increasing levels of prolonged, sustained endurance training improves diastolic function, slows the progression of presbycardia, and may help to prevent heart failure in the elderly.Lifelong Exercise Training Demonstrates a Dose Dependent Effect on Left Ventricular Compliance and Distensibility: 603: June 2 11:00 AM - 11:15 AMHastings, Jeffrey L.; Bhella, Paul S.; Shibata, Shigeki; Fujimoto, Naoki; Carrick-Ranson, Graeme; Minniefield, Nicole; McLoughlin, James; Boyd, Kara; Palmer, M D.; Levine, Benjamin D. FACSMA-14 Free Communication/Slide - Cardiac: JUNE 2, 2010 9:30 AM - 11:30 AM: ROOM: 331542