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00005768-200905001-0302000005768_2009_41_470_fatouros_supplementation_5miscellaneous< 16_0_1_0 >Medicine & Science in Sports & Exercise©2009The American College of Sports MedicineVolume 41(5) Supplement 1May 2009p 470L-carnitine Supplementation Improves Performance And Attenuates Oxidative Stress Responses In Renal Hemodialysis Patients: 2821: Board #215 May 29 2:00 PM - 3:30 PM[F-34 Free Communication/Poster - Supplements II: MAY 29, 2009 1:00 PM - 6:00 PM ROOM: Hall 4F]Fatouros, Ioannis G.1; Chatzinikolaou, Athanasios1; Panagoutsos, Stylianos2; Pasadakis, Ploumis2; Mourvati, Euthimia2; Sovatzidis, Apostolos2; Douroudos, Ioannis I.1; Michailidis, Yiannis1; Jamurtas, Athanasios Z.3; Jamurtas, Athanasios Z.3; Nikolaidis, Michalis G.3; Taxildaris, Kyriakos1; Vargemezis, Vassilios21Democritus University Of Thrace, Komotini, Greece. 2Democritus University Of Thrace, Alexandroupolis, Greece. 3University Of Thessaly, Trikala, Greece.Email: fatouros@otenet.gr(No relationships reported)Hemodialyzed patients (HD) demonstrate elevated oxidative stress and reduced functional status. Although exercise induces health benefits, acute exertion upregulates oxidative stress responses in HD patients. Carnitine has been postulated to have antioxidant properties.PURPOSE: To investigate the effects of L-carnitine (LCAR) supplementation on performance and oxidative stress responses of HD patients.METHODS: Twelve male HD patients (53.1±2.5 yrs) reveived either LCAR (intravenous infusion following each dialysis session, 20 mg/kg) or placebo (P, saline of equal dose) in a counterbalanced, double-blinded design, for eight weeks. Participants performed an exercise test to exhaustion before and post-supplementation. During the test, VO2, respiratory exchange ratio (RER), heart rate, and time-to-exhaustion were monitored. Blood samples, collected before and post-exercise, were analyzed for lactate, thiobarbituric acid-reactive substances (TBARS), protein carbonyls (PC), reduced (GSH) and oxidized glutathione (GSGG), antioxidant capacity (TAC), catalase, and glutathione peroxidase (GPX) activity.RESULTS: Blood carnitine increased only in LCAR post-supplementation proportionately at rest and post-exercise. LCAR increased endurance (22%), decreased lactate (37%), RER, and submaximal heart rate but did not affect VO2peak. LCAR ingestion reduced TBARS by 19% and 10%, PC by 40% and 27%, and increased GSH/GSSG by 2.7-fold and 4-fold, at rest and post-exercise respectively, while increased GPX activity post-exercise by 10%.CONCLUSIONS: The results of the present investigation suggest that LCAR intravenous infusion for two months may be effective in attenuating oxidative stress responses, enhancing antioxidant status, and improving performance of patients undergoing chronic haemodialysis treatment.L-carnitine Supplementation Improves Performance And Attenuates Oxidative Stress Responses In Renal Hemodialysis Patients: 2821: Board #215 May 29 2:00 PM - 3:30 PMFatouros, Ioannis G.; Chatzinikolaou, Athanasios; Panagoutsos, Stylianos; Pasadakis, Ploumis; Mourvati, Euthimia; Sovatzidis, Apostolos; Douroudos, Ioannis I.; Michailidis, Yiannis; Jamurtas, Athanasios Z.; Jamurtas, Athanasios Z.; Nikolaidis, Michalis G.; Taxildaris, Kyriakos; Vargemezis, VassiliosF-34 Free Communication/Poster - Supplements II: MAY 29, 2009 1:00 PM - 6:00 PM ROOM: Hall 4F541