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00005768-200905001-0292300005768_2009_41_439_lobelo_associations_5miscellaneous< 16_0_1_0 >Medicine & Science in Sports & Exercise©2009The American College of Sports MedicineVolume 41(5) Supplement 1May 2009pp 439-440Associations Between Objectively-measured Physical Activity And Clustered Cvd Risk In Adolescents: Nhanes 2003-2006: 2723: Board #117 May 29 2:00 PM - 3:30 PM[F-28 Free Communication/Poster - Physical Activity and Chronic Disease: MAY 29, 2009 1:00 PM - 6:00 PM ROOM: Hall 4F]Lobelo, Felipe1; Pate, Russell R. FACSM2; Liese, Angela D.2; Meriwether, Rebecca2; Riner, William2; Pratt, Michael FACSM31EIS Officer - Centers for Disease Control and Prevention, Atlanta, GA. 2University of South Carolina, Columbia, SC. 3Centers for Disease Control and Prevention, Atlanta, GA.Email: hgn0@cdc.gov(No relationships reported)Cardiovascular disease (CVD) is accelerated by the clustering of CVD risk factors/metabolic syndrome, which in adults is strongly associated to physical activity (PA). However, this association has not been well studied in adolescents.PURPOSE: To assess the association between clustered CVD risk and objectively-measured PA in a population-based sample of U.S. adolescents.METHODS: Complete data on PA and CVD risk were available for 983 adolescents (mean age 15.3 ± 2.3 years; 47.4% female) in the 2003-2004 and 2005-2006 NHANES cohorts. PA was measured with an ActiGraph AM-7164 accelerometer. At least 10 hours/day on 4 days were required for a valid record. Mean mins/day of moderate-to-vigorous physical activity (MVPA) and the proportion achieving the recommended 60 mins/day were calculated. A standardized CVD clustering score (MetSyn) relative to the International Diabetes Federation pediatric metabolic syndrome definition was constructed using age group- and gender-standardized values for waist circumference (WC), mean arterial blood pressure, fasting glucose, HDL-cholesterol and triglycerides. Positive scores indicate higher CVD risk. A second score was calculated without WC (MetSyn-WC) to assess the confounding effect of adiposity. Regression analyses were used to assess the associations between PA (independent variable) and MetSyn (dependent variable) while adjusting for monitor wear time, age, gender, race/ethnicity and socio-economic status as well as WC.RESULTS: MVPA quintiles (Q) were <10, 11-21, 22-32, 33-52 and 53+ mins. MetSyn ranged from -3.04 to 1.87, with a mean of -1.37 (0.63). After adjusting for socio-demographic factors, a negative association was found between MetSyn and MVPA quintiles (p=0.009) but it weakened after further adjustment by WC (p=0.06). The mean MetSyn value for the first Q of MVPA differed from all the other Q (p<0.04). Lower MetSyn and MetSyn-WC values were found for youth meeting vs. not meeting the MVPA recommendation (p=0.02 and p=0.03, respectively).CONCLUSIONS: A negative graded association was found between MVPA and MetSyn among U.S. adolescents. The association weakened after further adjustment by WC. MetSyn is lower in adolescents meeting the MVPA recommendations but those accumulating at least 11 mins of MVPA/day already exhibit lower MetSyn values.Associations Between Objectively-measured Physical Activity And Clustered Cvd Risk In Adolescents: Nhanes 2003-2006: 2723: Board #117 May 29 2:00 PM - 3:30 PMLobelo, Felipe; Pate, Russell R. FACSM; Liese, Angela D.; Meriwether, Rebecca; Riner, William; Pratt, Michael FACSMF-28 Free Communication/Poster - Physical Activity and Chronic Disease: MAY 29, 2009 1:00 PM - 6:00 PM ROOM: Hall 4F541