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00005768-200812000-0001900005768_2008_40_2145_graver_statistical_12book-or-media-review< 24_0_6_0 >Medicine & Science in Sports & Exercise©2008The American College of Sports MedicineVolume 40(12)December 2008p 2145Statistical Genetics: Gene Mapping Through Linkage and Association[SPECIAL COMMUNICATIONS: Book Reviews]Graver, Christopher PhD(Madigan Army Medical Center, Fort Lewis, WA)Editors: Neale, Benjamin M., Ferreira, Manuel A. R., Medland, Sarah E., Posthuma, Danielle. Bibliographic Data: (ISBN: 978-0-4154-1040-3) 608 pages, paperback. Specialties: Psychology, Clinical, Epidemiology, Genetics. Publisher: Informa Healthcare/Taylor & Francis. List Price: $76.00.DESCRIPTION:Studies regarding the genetic contributions to human behavior and disease have been invaluable in identifying hereditary components, biological versus social constructs, and the interactions between genes and other factors. This book provides a guide to methodologies and technologies which optimize research in this field.PURPOSE:Arising from the 2005 Workshop on Methodology for Twin and Family Studies, this book applies structural equation modeling (SEM) to the areas of behavioral genetics and genetic epidemiology.AUDIENCE:Researchers and graduate students in the field of behavioral genetics and related fields, such as public health, psychology, sociology, biology, and medicine. This text is written at a fairly advanced level that assumes familiarity with genetics, SEM, and associated computer programs. The editors are a young group of promising scholars backed by senior faculty chapter authors.FEATURES:For readers new to this field, the book starts with an introduction to genetics and other concepts of importance, such as statistical power. Each chapter builds upon the last, so that novice readers would be well advised to read the book from beginning to end. Advanced readers will be able to skip ahead to chapters of specific interest. Both linkage analysis and association models are covered in depth. There is a chapter specific to learning PLINK with sample Unix commands and binary files. For users of Haploview, there is a discussion of this program, screen shots, and specific tips for running linkage disequilibrium analysis and tagging. The two chapters on Power and Type I Error in linkage and association studies are useful additions. Figures and tables supplement the text. The references are well researched and current, but the index is somewhat abbreviated for a book of this size.ASSESSMENT:This is a commendable account of statistical genetics, particularly in relation to linkage analysis and association models. Although the subject matter is rather specific and presented at an intermediate-to-advanced level, students and researchers in this field will find it abundantly useful.RATING: ★★★★Reviewed by:Christopher Graver, PhD(Madigan Army Medical Center, Fort Lewis, WA)Statistical Genetics: Gene Mapping Through Linkage and AssociationGraver, Christopher PhDSPECIAL COMMUNICATIONS: Book Reviews1240