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00005768-200805001-0113900005768_2008_40_s103_bard_combination_5miscellaneous< 16_0_1_1 >Medicine & Science in Sports & Exercise©2008The American College of Sports MedicineVolume 40(5) Supplement 1May 2008p S103Superior Prognostic Ability of Systolic Blood Pressure in Combination with Ventilatory Efficiency as Compared to Peak Oxygen Consumption: 962: May 30 3:15 PM - 3:30 PM[F-47 Free Communication/Slide - Clinical Exercise Testing: May 30, 2008 3:15 PM - 5:00 PM ROOM: 106]Bard, Robert L.; Gillespie, Brenda W.; Nicklas, John M.University of Michigan, Ann Arbor, MI.(No relationships reported)PURPOSE: The purpose of this study was to determine the effects of other clinical measures on the mortality prediction of VE/VCO2 slope.METHODS: Heart failure patients underwent cardiopulmonary exercise testing and had follow-up for at least 5 years. Cox regression analysis identified significant mortality predictors where an event was defined as death or emergent transplant. A model that best predicted mortality was obtained and patients were deemed more ill were identified by having VE/VCO2 slope≥45, SBP≤100mm Hg, and peak VO2≤14 ml•kg•min-1.RESULTS: Mean age was 51 ± 10 years in 355 HF patients. In order of predictive ability, the best model included: VE/VCO2 slope (37.0 ± 9.0), SBP ≤100 mm Hg (113±18 mm Hg), peak VO2 (17.3±5.0 ml•kg•min-1), heart rate ≥80 beats·min-1 (82±16 beats·min-1), sex (male), ejection fraction (22±8%), and etiology (ischemic). Beta blockade was not significant within the model. Patients with a combination of poor VE/VCO2 slope and poor SBP had 25% survival (Figure) and patients with a combination of poor VE/VCO2 slope and poor VO2 had 30% survival.CONCLUSIONS: SBP provided more predictive information than peak VO2, whether considered by itself or along with poor ventilatory efficiency.Figure. Caption not provided.Superior Prognostic Ability of Systolic Blood Pressure in Combination with Ventilatory Efficiency as Compared to Peak Oxygen Consumption: 962: May 30 3:15 PM - 3:30 PMBard, Robert L.; Gillespie, Brenda W.; Nicklas, John M.F-47 Free Communication/Slide - Clinical Exercise Testing: May 30, 2008 3:15 PM - 5:00 PM ROOM: 106540