Share this article on:

00005768-200305001-0185100005768_2003_35_s333_colbert_inflammatory_5miscellaneous< 17_0_5_0 >Medicine & Science in Sports & Exercise©2003The American College of Sports MedicineVolume 35(5) Supplement 1May 2003p S333PHYSICAL ACTIVITY AND INFLAMMATORY MARKERS IN OLDER ADULTS[G-15O FREE COMMUNICATION/POSTER EPIDEMIOLOGY]Colbert, L H.1; Visser, M1; Simonsick, E M.1; Tracy, R P.1; Newman, A B.1; Kritchevsky, S B.1; Pahor, M1; Taaffe, D R. FACSM1; Brach, J1; Rubin, S M.1; Harris, T B.11National Institute on Aging, Bethesda, MDPURPOSETo examine the association between physical activity and inflammation in older adults.METHODSCross-sectional analysis of baseline data from the Health, Aging, and Body Composition Study, consisting of a biracial cohort of 3,075 well-functioning men and women aged 70–79, from the Pittsburgh, PA and Memphis, TN areas. An interview-administered questionnaire assessed past-week household, occupational/volunteer activities, walking, and exercise. Serum C-reactive protein (CRP), interleukin-6 (IL-6), and plasma tumor necrosis factor-α (TNFα) were measured as markers of systemic inflammation. Analysis of covariance was used to examine inflammation by activity level with adjustment for specific covariates. Use of anti-oxidant supplements (multivitamin, vitamins E or C, beta carotene) was evaluated as an effect modifier of the association.RESULTSHigher levels of exercise were inversely associated with lower levels of CRP (p < 0.01), IL-6 (p < 0.001), and TNFα(p = 0.02). Adjustment for body fatness attenuated these associations somewhat: CRP (p = 0.10), IL-6 (p < 0.01), and TNFα (p = 0.07). Use of anti-oxidant supplements modified the fully adjusted associations with CRP (pint=0.01), and to a lesser degree IL-6 (pint=0.08) such that the association with physical activity was present in those not taking supplements (CRP, p = 0.02; IL-6, p = 0.01) but not among those taking the supplements (CRP, p = 0.90; IL-6, p = 0.21). Among those who did no exercise, higher levels of total physical activity were also related to lower levels of CRP (p < 0.01) and IL-6 (p = 0.02), but not TNFα (p = 0.36) even accounting for body fat.CONCLUSIONPhysical activity and exercise are associated with lower levels of systemic inflammation in older adults, and differences in body fatness do not fully explain this association. There is no relationship between exercise and inflammation in those who take antioxidant supplements. Supported by NIH contracts N01-AG-6–2101, N01-AG-6–2103, and N01-AG-6–2106.PHYSICAL ACTIVITY AND INFLAMMATORY MARKERS IN OLDER ADULTSColbert, L H.; Visser, M; Simonsick, E M.; Tracy, R P.; Newman, A B.; Kritchevsky, S B.; Pahor, M; Taaffe, D R. FACSM; Brach, J; Rubin, S M.; Harris, T B.G-15O Free Communication/Poster Epidemiology535