Skip Navigation LinksHome > November 2013 - Volume 45 - Issue 11 > Sprint Interval Training in Hypoxia Stimulates Glycolytic En...
Medicine & Science in Sports & Exercise:
doi: 10.1249/MSS.0b013e31829734ae
Applied Sciences

Sprint Interval Training in Hypoxia Stimulates Glycolytic Enzyme Activity


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Purpose: In this study, we compared the effect of sprint interval training (SIT) in normoxia versus hypoxia on muscle glycolytic and oxidative capacity, monocarboxylate transporter content, and endurance exercise performance.

Methods: Healthy male volunteers (18–30 yr) performed 6 wk of SIT on a cycling ergometer (30-s sprints vs 4.5-min rest intervals; 3 d·wk−1) in either normobaric hypoxia (HYP, FiO2 = 14.4%, n = 10) or normoxia (NOR, FiO2 = 20.9%, n = 9). The control group did not train (CON, n = 10). Training load was increased from four sprints per session in week 1 to nine sprints in week 6. Before and after SIT, subjects performed a maximal incremental exercise test plus a 10-min simulated time trial on a cycle ergometer in both normoxia (MAXnor and TTnor) and hypoxia (MAXhyp and TThyp). A needle biopsy was taken from musculus vastus lateralis at rest 5–6 d after the last exercise session.

Results: SIT increased muscle phosphofructokinase activity more in HYP (+59%, P < 0.05) than that in NOR (+17%), whereas citrate synthase activity was similar between groups. Compared with the pretest, power outputs corresponding to 4 mmol blood lactate in HYP during MAXnor (+7%) and MAXhyp (+9%) were slightly increased (P < 0.05), whereas values were constant in NOR. V˙O2max in MAXnor and TT performance in TTnor and TThyp were increased by ∼6%–8% (P < 0.05) in either group. The training elevated monocarboxylate transporter 1 protein content by ∼70% (P < 0.05). In CON, all measurements were constant throughout the study.

Conclusion: SIT in hypoxia up-regulated muscle phosphofructokinase activity and the anaerobic threshold more than SIT in normoxia but did not enhance endurance exercise performance.

© 2013 American College of Sports Medicine


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