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Medicine & Science in Sports & Exercise:
doi: 10.1249/MSS.0b013e3182496a25
Clinical Sciences

Physical Activity Increases Bone Mineral Density in Children with Type 1 Diabetes

MAGGIO, ALBANE B. R.1,4; RIZZOLI, RENÉ R.2; MARCHAND, LAETITIA M.1; FERRARI, SERGE2; BEGHETTI, MAURICE3; FARPOUR-LAMBERT, NATHALIE JACQUELINE1

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Abstract

Introduction: Osteoporosis is a growing health problem in patients with type 1 diabetes mellitus (T1DM). The aim of this study was to determine the effects of a 9-month weight-bearing physical activity program on bone mineral density (BMD) and bone biomarkers in T1DM compared with healthy children.

Methods: This was a randomized controlled trial including 27 diabetic and 32 healthy children (mean age = 10.5 ± 2.5 yr). Both T1DM and healthy participants were randomized to either an exercise or a control group (i.e., four groups). At baseline and 9 months, total body (TB), lumbar spine (LS2–LS4), femoral neck, and greater trochanter areal BMD (aBMD) and serum bone biomarkers (osteocalcin, type 1 collagen cross-linking) were measured. The intervention consisted of two 90-min sessions per week of weight-bearing physical activity (ball games, jumping, rope skipping, and gymnastics).

Results: Baseline variables were similar among groups. At 9 months, changes in TB (T1DM = 0.035 ± 0.022 g·cm−2, healthy = 0.031 ± 0.017 g·cm−2) and LS2–LS4 (T1DM = 0.046 ± 0.038 g·cm−2, healthy = 0.063 ± 0.034 g·cm−2) aBMD were statistically significant in the intervention groups and of similar magnitude between T1DM and healthy subjects. The level of type 1 collagen cross-linking (T1DM = −0.12 ± 0.32 ng·mL−1, healthy = −0.36 ± 0.11 ng·mL−1) decreased in the intervention groups but was not associated with TB aBMD changes.

Conclusions: Regular weight-bearing physical activity (180 min·wk−1, including ball games, jumping activities, and gymnastics) improves total and LS2–LS4 bone mineral accretion in children with T1DM, in a similar magnitude to healthy subjects. We conclude that children with T1DM should be encouraged to practice regular physical activity to enhance peak bone mass and prevent osteoporosis later in life.

©2012The American College of Sports Medicine

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