Remote Preconditioning Improves Maximal Performance in Highly Trained Athletes

JEAN-ST-MICHEL, EMILIE1; MANLHIOT, CEDRIC1; LI, JING1; TROPAK, MICHAEL1; MICHELSEN, MARIE M.2; SCHMIDT, MICHAEL R.2; MCCRINDLE, BRIAN W.1; WELLS, GREG D.1; REDINGTON, ANDREW N.1

Medicine & Science in Sports & Exercise: July 2011 - Volume 43 - Issue 7 - pp 1280-1286
doi: 10.1249/MSS.0b013e318206845d
Applied Sciences

Background: Remote ischemic preconditioning (RIPC) induced by transient limb ischemia releases a dialysable circulating protective factor that reduces ischemia-reperfusion injury. Exercise performance in highly trained athletes is limited by tissue hypoxemia and acidosis, which may therefore represent a type of ischemia-reperfusion stress modifiable by RIPC.

Methods and Results: National-level swimmers, 13-27 yr, were randomized to RIPC (four cycles of 5-min arm ischemia/5-min reperfusion) or a low-pressure control procedure, with crossover. In study 1, subjects (n = 16) performed two incremental submaximal swimming tests with measurement of swimming velocity, blood lactate, and HR. For study 2, subjects (n = 18) performed two maximal competitive swims (time trials). To examine possible mechanisms, blood samples taken before and after RIPC were dialysed and used to perfuse mouse hearts (n = 10) in a Langendorff preparation. Infarct sizes were compared with dialysate obtained from nonathletic controls. RIPC released a protective factor into the bloodstream, which reduced infarct size in mice (P < 0.05 for controls and swimmers). There was no statistically significant difference between the effect of RIPC and the low-pressure control protocol on submaximal exercise performance. However, RIPC was associated with a mean improvement of maximal swim time for 100 m of 0.7 s (P = 0.04), an improvement in swim time relative to personal best time (−1.1%, P = 0.02), and a significant improvement in average International Swimming Federation points (+22 points, P = 0.01).

Conclusions: RIPC improves maximal performance in highly trained swimmers. This simple technique may be applicable to other sports and, more importantly, to other clinical syndromes in which exercise tolerance is limited by tissue hypoxemia or ischemia.

1The Hospital for Sick Children, University of Toronto, Toronto, Ontario, CANADA; and 2Institute of Clinical Medicine, Aarhus University, Aarhus, DENMARK

Address for correspondence: Andrew N. Redington, M.D., Division of Cardiology, Hospital for Sick Children, 555 University Ave., Toronto, Ontario, Canada M5G 1X8; E-mail: andrew.redington@sickkids.ca.

Submitted for publication July 2010.

Accepted for publication November 2010.

© 2011 American College of Sports Medicine