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Neuromuscular Recovery after Medial Collateral Ligament Disruption and Eccentric Rehabilitation Program

LAURIN, JÉRÔME; DOUSSET, ERICK; MESURE, SERGE; DECHERCHI, PATRICK

Medicine & Science in Sports & Exercise: June 2011 - Volume 43 - Issue 6 - p 1032-1041
doi: 10.1249/MSS.0b013e3182042956
Basic Sciences

Purpose: Medial collateral ligament (MCL) rupture of the knee joint frequently occurs during sport activities. However, the optimal rehabilitation strategy after such lesion is unknown. The aim of this study was to assess the effects of progressive eccentric rehabilitation program on neuromuscular deficits induced by MCL transection.

Methods: Rats were randomized as follows: (i) control group (C, n = 10) without any surgery; (ii) lesion groups in which neuromuscular measurements were made 1 (L1, n = 10) and 3 wk (L3, n = 9) after MCL transection by a 15- to 20-min surgery (this group was designed to determine changes induced by the MCL transection); and (iii) eccentric group (ECC, n = 7) in which rats performed a progressive 2-wk eccentric rehabilitation program beginning 1 wk after MCL transection surgery. Dynamic functional assessments were performed at weeks 1 and 3 after the MCL transection by measuring the maximal and minimal knee angles during the stance phase of the gait cycle. Neuromuscular measurements included 1) modulation of H-reflex in response to a 10-mM KCl injection, 2) analysis of the twitch relaxation properties of the quadriceps muscle, and 3) recording of metabosensitive and mechanosensitive afferents activity in response to chemical injections and to tendon patellar vibrations, respectively.

Results: Our results indicated that H-reflex modulation induced by metabosensitive afferents was disturbed by MCL transection without any recovery despite rehabilitation program. Responses of both metabosensitive and mechanosensitive muscle afferents, as well as the muscle relaxation properties, were fully recovered after the eccentric rehabilitation program.

Conclusions: Our results directly indicated an influence of progressive eccentric program on muscle afferents response after MCL section but apparently not for spinal reflex modulation.

UMR CNRS 6233, Institut des Sciences du Mouvement: Etienne-Jules Marey, Equipe Plasticité des Systèmes Nerveux et Musculaire, Université de la Méditerranée (Aix-Marseille II) - Aix-Marseille Université, Faculté des Sciences du Sport, Parc Scientifique et Technologique de Luminy, Marseille, FRANCE

Address for correspondence: Erick Dousset, Ph.D., UMR CNRS 6233, Institut des Sciences du Mouvement: Etienne-Jules Marey, Equipe Plasticité des Systèmes Nerveux et Musculaire, Université de la Méditerranée(Aix-Marseille II) - Aix-Marseille Université, Faculté des Sciences du Sport, Parc Scientifique et Technologique de Luminy, CC910 - 163 Avenue de Luminy, F-13288 Marseille cedex 09, France; E-mail: erick.dousset@univmed.fr.

Submitted for publication March 2010.

Accepted for publication October 2010.

©2011The American College of Sports Medicine