Plasma Pentraxin 3 Concentration Increases in Endurance-Trained Men

MIYAKI, ASAKO1; MAEDA, SEIJI1; OTSUKI, TAKESHI2; AJISAKA, RYUICHI1

Medicine & Science in Sports & Exercise:
doi: 10.1249/MSS.0b013e3181e84bce
Basic Sciences
Abstract

Introduction: Pentraxin 3 (PTX3), which is mainly produced by endothelial cells, macrophages, and smooth muscle cells in the atherosclerotic region, has a cardioprotective effect. Endurance exercise training has also been known to offer cardioprotection. However, the effect of regular endurance exercise on PTX3 is unknown. This study aimed to investigate whether plasma PTX3 concentrations increase in endurance-trained men. Ten young endurance-trained men and 12 age- and gender-matched sedentary controls participated in this study.

Methods: We measured plasma PTX3 concentrations of the participants in each group. We also determined systemic arterial compliance (SAC) by using simultaneous M-mode ultrasound and arterial applanation tonometry of the common carotid artery and used HDL cholesterol (HDLC) as an index of cardioprotective effect.

Results: Maximal oxygen uptake was significantly higher in the endurance-trained men than that in the sedentary controls. SAC and HDLC were significantly higher in the endurance-trained men than that in the sedentary controls (SAC = 1.74 ± 0.11 vs 1.41 ± 0.09 mL·mm Hg−1, P < 0.05; HDLC = 70 ± 5 vs 57 ± 4 mg·dL−1, P < 0.05). Plasma PTX3 concentrations were markedly higher in the endurance-trained men than that in the sedentary controls (0.93 ± 0.11 vs 0.68 ± 0.06 ng·mL−1, P < 0.05). Relationships between plasma PTX3 concentrations and SAC and HDLC were linear.

Conclusions: This is the first study revealing that endurance-trained individuals had higher levels of circulating PTX3 than sedentary controls. PTX3 may play a partial role in endurance exercise training-induced cardioprotection.

Author Information

1Division of Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, JAPAN; and 2Graduate School of Health and Sport Sciences, Ryutsu Keizai University, Ryugasaki, Ibaraki, JAPAN

Submitted for publication December 2009.

Accepted for publication May 2010.

Address for correspondence: Seiji Maeda, Ph.D., Division of Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan; E-mail: maeda@taiiku.tsukuba.ac.jp.

©2011The American College of Sports Medicine