Neuromuscular and Hormonal Responses to Constant and Variable Resistance Loadings

WALKER, SIMON1; TAIPALE, RITVA S.1; NYMAN, KAI2; KRAEMER, WILLIAM J.3; HÄKKINEN, KEIJO1

Medicine & Science in Sports & Exercise: January 2011 - Volume 43 - Issue 1 - pp 26-33
doi: 10.1249/MSS.0b013e3181e71bcb
Basic Sciences

Purpose: The purpose of this study was to investigate the acute effects of constant and variable resistance exercise on neuromuscular and endocrine responses during maximal strength and hypertrophic loadings.

Methods: Thirteen young men (age = 28.4 ± 3.7 yr) took part in four loadings (maximal strength and hypertrophic loadings using both constant and variable resistance) in a counterbalanced order. Maximal strength loadings consisted of 15 sets of one repetition at 100% one-repetition maximum, and hypertrophic loadings consisted of five sets of 10 repetitions (initial load of 80% one-repetition maximum). Preloading, immediately postloading, 15 min postloading, and 30 min postloading tests consisted of maximal bilateral isometric leg press, venous blood samples (analyzed for total testosterone, growth hormone, and cortisol), and fingertip blood lactate samples. Concentric force and vastus lateralis, vastus medialis, rectus femoris, and biceps femoris EMG was recorded throughout each loading protocol and analyzed over 20° segments.

Results: Force and quadriceps EMG was greater from 120° to 180° knee angle (P < 0.05) during variable resistance hypertrophic loadings. Larger increases in concentric quadriceps muscle activation and slower recovery in isometric force and muscle activation were observed during variable resistance hypertrophic loadings. Preloading to postloading serum total testosterone, growth hormone, and cortisol concentration increased during variable resistance hypertrophic loading, whereas during constant resistance loadings, only growth hormone increased (P = 0.051). During 30 min postloading, growth hormone and cortisol concentrations remained elevated after both hypertrophic loadings.

Conclusions: A greater level of neuromuscular fatigue and larger responses in serum hormone concentrations occurred after hypertrophic variable resistance loading. These findings indicate greater fatigability during variable resistance loading and that this fatigability influences acute hormonal responses.

1Department of Biology of Physical Activity and Neuromuscular Research Center, University of Jyväskylä, Jyväskylä, FINLAND; 2Central Hospital of Jyväskylä, FINLAND; and 3Human Performance Laboratory, Department of Kinesiology/Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT

Address for correspondence: Simon Walker, M.Sc., Department of Biology of Physical Activity, University of Jyväskylä, PO Box 35 (VIV), 40014, Jyväskylä, Finland; E-mail: simon.walker@jyu.fi.

Submitted for publication April 2010.

Accepted for publication May 2010.

©2011The American College of Sports Medicine