Home Current Issue Previous Issues Published Ahead-of-Print Collections For Authors Journal Info
Skip Navigation LinksHome > December 2010 - Volume 42 - Issue 12 > Exercise Intensity, Inflammatory Signaling, and Insulin Resi...
Medicine & Science in Sports & Exercise:
doi: 10.1249/MSS.0b013e3181e45d08
Basic Sciences

Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats

DA SILVA, ADELINO S. R.1,2; PAULI, JOSÉ R.1,3; ROPELLE, EDUARDO R.1; OLIVEIRA, ALEXANDRE G.1; CINTRA, DENNYS E.1; DE SOUZA, CLAUDIO T.1,4; VELLOSO, LÍCIO A.1; CARVALHEIRA, JOSÉ B. C.1; SAAD, MARIO J. A.1

Collapse Box

Abstract

Purpose: To evaluate the effects of intensity of exercise on insulin resistance and the expression of inflammatory proteins in the skeletal muscle of diet-induced obese (DIO) rats after a single bout of exercise.

Methods: In the first exercise protocol, the rats swam for two 3-h bouts, separated by a 45-min rest period (with 6 h in duration-DIO + EXE), and in the second protocol, the rats were exercised with 45 min of swimming at 70% of the maximal lactate steady state-MLSS (DIO + MLSS).

Results: Our data demonstrated that both protocols of exercise increased insulin sensitivity and increased insulin-stimulated tyrosine phosphorylation of insulin receptor and insulin receptor substrate 1 and serine phosphorylation of protein kinase B in the muscle of DIO rats by the same magnitude. In parallel, both exercise protocols also reduced protein tyrosine phosphatase 1B activity and insulin receptor substrate 1 serine phosphorylation, with concomitant reduction in c-jun N-terminal kinase and IκB kinase activities in the muscle of DIO rats in a similar fashion.

Conclusions: Thus, our data demonstrate that either exercise protocols with low intensity and high volume or exercise with moderate intensity and low volume represents different strategies to restore insulin sensitivity with the same efficacy.

©2010The American College of Sports Medicine

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.

Connect With Us