Mechanisms for Increases in VO2max with Endurance Training in Older and Young Women

MURIAS, JUAN M.1,2; KOWALCHUK, JOHN M.1,2,3; PATERSON, DONALD H.1,2

Medicine & Science in Sports & Exercise:
doi: 10.1249/MSS.0b013e3181dd0bba
Basic Sciences
Abstract

Purpose: To examine the time course and mechanisms of cardiorespiratory fitness adaptation to training in older (O) and young (Y) women.

Methods: A total of six O (69 ± 7 yr) and eight Y (25 ± 5 yr) women were examined before training and after 3, 6, 9, and 12 wk of training. Training was performed on a cycle ergometer three times per week for 45 min at ∼70% of V˙O2max.

Results: V˙O2max (mL·kg−1·min−1) increased within 3 wk, with further changes observed at weeks 6 and 9 in both O (17% ± 14%) and Y and also posttraining (12 wk) in Y (22% ± 6%, P < 0.05). Maximal cardiac output (max, open-circuit acetylene) and stroke volume increased only in Y after 9 wk of training (P < 0.05). Age × testing time interactions in maximal arterial-venous O2 difference (a-vO2diff) after 6 wk of training revealed a greater dependence on a-vO2diff in O compared with Y (P < 0.05); ∼65% of the change in V˙O2max from pretraining to posttraining was explained by a widened maximal a-vO2diff in O compared with almost equal increases in max and maximal a-vO2diff in Y. The early adaptations (first 3 wk) in O relied exclusively on a nonsignificant increase in max, whereas Y depended on a widened maximal a-vO2diff. Later changes in V˙O2max were explained exclusively by an improved maximal a-vO2diff in O and a larger max in Y.

Conclusions: O and Y women displayed a different time course of training adaptation in V˙O2max, with Y (after an initial improvement in maximal a-vO2diff) depending more on changes in max and O mostly relying on a widened maximal a-vO2diff.

Author Information

1Canadian Centre for Activity and Aging, University of Western Ontario, London, Ontario, CANADA; 2School of Kinesiology, University of Western Ontario, London, Ontario, CANADA; and 3Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, CANADA

Address for correspondence: Donald H. Paterson, Ph.D., School of Kinesiology, University of Western Ontario, London, Ontario, Canada N6A 3K7; E-mail: dpaterso@uwo.ca.

Submitted for publication November 2009.

Accepted for publication March 2010.

©2010The American College of Sports Medicine