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Effect of Caffeine Ingestion on Muscular Strength and Endurance: A Meta-Analysis

WARREN, GORDON L.1; PARK, NICOLE D.1; MARESCA, ROBERT D.1; MCKIBANS, KIMBERLY I.1; MILLARD-STAFFORD, MELINDA L.2

Medicine & Science in Sports & Exercise: July 2010 - Volume 42 - Issue 7 - p 1375-1387
doi: 10.1249/MSS.0b013e3181cabbd8
Applied Sciences

Purpose: Our objective was to perform a systematic review and meta-analysis of the research literature assessing the effect of caffeine ingestion on maximal voluntary contraction (MVC) strength and muscular endurance.

Methods: Thirty-four relevant studies between 1939 and 2008 were included in the meta-analyses of caffeine's effects on MVC strength (n = 27 studies) and muscular endurance (n = 23 studies). Effect sizes (ES) were calculated as the standardized mean difference and meta-analyses were completed using a random-effects model.

Results: Overall, caffeine ingestion was found to result in a small beneficial effect on MVC strength (overall ES = 0.19, P = 0.0003). However, caffeine appears to improve MVC strength primarily in the knee extensors (i.e., by ∼7%, ES = 0.37) and not in other muscle groups such as the forearm or the knee flexors. In an attempt to offer a physiological mechanism behind caffeine's ability to improve MVC strength, a meta-analysis was run on ES from nine studies that measured percent muscle activation during MVC in trials comparing caffeine versus placebo; the overall ES (0.67) was highly significant (P = 0.00008) and of moderate to large size, thus implicating an effect of caffeine on the CNS. Caffeine ingestion was also found to exert a small beneficial effect on muscular endurance (overall ES = 0.28, P = 0.00005). However, it appears caffeine improves muscular endurance only when it is assessed using open (i.e., by ∼18%, ES = 0.37) and not fixed end point tests.

Conclusions: Overall, caffeine ingestion improves MVC strength and muscular endurance. The effect on strength appears exclusively in the knee extensors, and the effect on muscular endurance appears only detectable with open end point tests.

1Division of Physical Therapy, Georgia State University, Atlanta, GA; and 2School of Applied Physiology, Georgia Institute of Technology, Atlanta, GA

Address for correspondence: Gordon L. Warren, Ph.D., Division of Physical Therapy, PO Box 4019, Georgia State University, Atlanta, GA 30302-4019; E-mail: gwarren@gsu.edu.

Submitted for publication July 2009.

Accepted for publication November 2009.

©2010The American College of Sports Medicine