Skip Navigation LinksHome > July 2010 - Volume 42 - Issue 7 > Carbohydrate Supplementation and Sex Differences in Fuel Sel...
Medicine & Science in Sports & Exercise:
doi: 10.1249/MSS.0b013e3181cbba0b
BASIC SCIENCES: Contrasting Perspectives

Carbohydrate Supplementation and Sex Differences in Fuel Selection during Exercise


Collapse Box


Purpose: To compare the effects of a high-CHO diet (80% CHO) and glucose ingestion (2 g·kg−1) during exercise (120 min, 57% V˙O2max) on fuel selection in women taking (W+OC) or not (W−OC) oral contraceptives and in men (six in each group).

Methods: Substrate oxidation was measured using indirect respiratory calorimetry in combination with a tracer technique to compute the oxidation of exogenous (13C-glucose) and endogenous CHO.

Results: In the control situation (mixed diet with water ingestion during exercise), the percent contribution to the energy yield (%En) of CHO oxidation was higher in men than in women (62 vs 53 %En). The high-CHO diet and glucose ingestion during exercise separately increased the %En from CHO oxidation in both men (+12%) and women (+24%), and the sex difference observed in the control situation disappeared. However, the increase in the %En from total CHO oxidation observed when glucose was ingested during exercise and when combined with a high-CHO diet was larger in women than in men (+47 vs +17 %En). This was not attributable to a higher %En from exogenous glucose oxidation in women, for which no sex difference was observed (25 and 27 %En in men and women), but was attributable to a smaller decrease in endogenous glucose oxidation. No significant difference in fuel selection was observed between W+OC and W−OC.

Conclusions: The increase in total CHO oxidation after the high-CHO diet was not different between sexes. Glucose ingestion during exercise, separately and combined to the high-CHO diet, had a greater effect in women than in men; this was mostly attributable to the smaller reduction in endogenous CHO oxidation.

©2010The American College of Sports Medicine


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.

Connect With Us