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Epicardial Fat Tissue: Relationship with Cardiorespiratory Fitness in Men

KIM, MAENG-KYU1; TANAKA, KIYOJI1; KIM, MI-JI1; MATSUO, TOMOAKI1; TOMITA, TSUGIO2; OHKUBO, HIROYUKI1; MAEDA, SEIJI1,3; AJISAKA, RYUICHI1

Medicine & Science in Sports & Exercise: March 2010 - Volume 42 - Issue 3 - pp 463-469
doi: 10.1249/MSS.0b013e3181b8b1f0
Baisc Sciences

Purpose: To explore the influence of the epicardial fat (EF) tissue on aspects of heart rate recovery (HRR) and cardiorespiratory fitness (V˙O2peak) in middle-aged men.

Methods: A cross-sectional analysis of EF thickness was performed on 101 overweight or obese men. The men were categorized into low-EF, moderate-EF, and high-EF groups on the basis of ventricular EF thickness, as measured by transthoracic echocardiography. V˙O2peak was assessed with a graded maximal cycle ergometric test, including measurement of HRR 2 min after test cessation to estimate parasympathetic activity, with assessment of several metabolic parameters.

Results: Men in the highest and the middle EF thickness tertile had significantly slower recovery times than subjects in the lowest tertile, respectively (P < 0.05). Subjects with higher EF thickness were more likely to have impaired recovery and to reveal lower cardiorespiratory fitness than low-EF group subjects. There was a significant partial correlation, adjusted by age and body weight, between EF thickness and V˙O2peak (r = -0.25, P = 0.014). In the hierarchical multiple linear regression analyses, EF thickness was the strongest predicting variable associated with V˙O2peak in these population (β = -1.182, P = 0.001).

Conclusions: Higher EF thickness in men is associated with lower HRR at 1 and 2 min, a representation of autonomic dysfunction and poor cardiorespiratory fitness. These data suggest that moderately obese men with thicker EF tissue demonstrate reduced cardiorespiratory fitness and a differing parasympathetic response to exercise testing, as compared with men with lower EF levels.

1Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, JAPAN; 2Department of Radiation, Higashi Toride Hospital, Ibaraki, JAPAN; and 3Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki, JAPAN

Address for correspondence: Maeng-Kyu Kim, Ph.D., Department of Sports Medicine for Health and Disease, University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan; E-mail: kimmk@stat.taiiku.tsukuba.ac.jp.

Submitted for publication April 2009.

Accepted for publication June 2009.

©2010The American College of Sports Medicine