Fuel Selection during Prolonged Arm and Leg Exercise with 13C-Glucose Ingestion

TREMBLAY, JONATHAN H.1; PÉRONNET, FRANÇOIS1; LAVOIE, CAROLE2; MASSICOTTE, DENIS3

Medicine & Science in Sports & Exercise:
doi: 10.1249/MSS.0b013e3181ab2579
Basic Sciences
Abstract

Purpose: To compare fuel selection during prolonged arm (AE) and leg exercise (LE) with water or glucose ingestion.

Methods: Ten subjects (V˙O2max: 4.77 ± 0.20 and 3.36 ± 0.15 L·min−1 for LE and AE, respectively) completed 120 min of LE and AE at 50% of the mode-specific maximal power output (353 ± 18 and 160 ± 9 W, respectively) with ingestion of water (20 mL·kg−1) or 13C-glucose (2 g·kg−1). Substrate oxidation was measured using indirect respiratory calorimetry corrected for urea excretion and 13CO2 production at the mouth.

Results: The contribution of protein oxidation to the energy yield (%En) was higher during AE than LE (∼8% vs ∼4%) because of the lower energy expenditure and was not significantly modified with glucose ingestion. With water ingestion, the %En from CHO oxidation was not significantly different during LE and AE (64 ± 2% and 66 ± 2%, respectively). Glucose ingestion significantly increased the %En from total CHO oxidation during AE (78 ± 3%) but not during LE (71 ± 2%). Exogenous glucose oxidation was not significantly different in AE and LE (56 ± 4 and 65 ± 3 g, respectively), but the %En from exogenous glucose was higher during AE than LE (30 ± 1% and 24 ± 1%) because of the lower energy expenditure. When glucose was ingested, the %En from endogenous CHO oxidation was significantly reduced during both AE (66 ± 2% to 48 ± 3%) and LE (64 ± 2% to 47 ± 3%) and was not significantly different in the two modes of exercise.

Conclusions: The difference in fuel selection between AE and LE when water was ingested was modest with a slightly higher reliance on CHO oxidation during AE. The amount of exogenous glucose oxidized was lower but its %En was higher during AE because of the lower energy expenditure.

Author Information

1Department of Kinesiology, University of Montreal, Montreal, Quebec, CANADA; 2Department of Exercise Sciences, University of Quebec in Trois-Rivieres, Trois-Rivieres, Quebec, CANADA; and 3Department of Kinanthropology, University of Quebec in Montreal, Montreal, Quebec, CANADA

Address for correspondence: Jonathan Tremblay, Department of Kinesiology, University of Montreal, C.P. 6128, succ. Centre Ville, Montreal, Quebec, Canada H3C 3J7; E-mail: jonathan.tremblay@umontreal.ca.

Submitted for publication January 2009.

Accepted for publication April 2009.

©2009The American College of Sports Medicine