Skip Navigation LinksHome > July 2009 - Volume 41 - Issue 7 > Exercise Training, NADPH Oxidase p22phox Gene Polymorphisms,...
Medicine & Science in Sports & Exercise:
doi: 10.1249/MSS.0b013e318199cee8
Basic Sciences

Exercise Training, NADPH Oxidase p22phox Gene Polymorphisms, and Hypertension

FEAIRHELLER, DEBORAH L.1; BROWN, MICHAEL D.1,2; PARK, JOON-YOUNG2,3; BRINKLEY, TINA E.2,4; BASU, SAMAR5; HAGBERG, JAMES M.2; FERRELL, ROBERT E.6; FENTY-STEWART, NICOLA M.1,2

Collapse Box

Abstract

Introduction: Oxidative stress that is mediated through NADPH oxidase activity plays a role in the pathology of hypertension, and aerobic exercise training reduces NADPH oxidase activity. The involvement of genetic variation in the p22phox (CYBA) subunit genes in individual oxidative stress responses to aerobic exercise training has yet to be examined in Pre and Stage 1 hypertensives.

Methods: Ninety-four sedentary Pre and Stage 1 hypertensive adults underwent 6 months of aerobic exercise training at a level of 70% V˙O2max to determine whether the CYBA polymorphisms, C242T and A640G, were associated with changes in urinary 8-iso-prostaglandin F (8-iso-PGF), urinary nitric oxide metabolites (NOx), and plasma total antioxidant capacity (TAC).

Results: Demographic and subject characteristics were similar among genotype groups for both polymorphisms. At baseline, a significant (P = 0.03) difference among the C2424T genotype groups in 8-iso-PGF levels was detected, with the TT homozygotes having the lowest levels and the CC homozygotes having the highest levels. However, no differences were found at baseline between the A640G genotype groups. After 6 months of aerobic exercise training, there was a significant increase in V˙O2max (P < 0.0001) in the entire study population. In addition, there were significant increases in both urinary 8-iso-PGF (P = 0.002) and plasma TAC (P=0.03) levels and a significant decrease in endogenous urinary NOx (P < 0.0001). Overall, aerobic exercise training elicited no significant differences among genotype groups in either CYBA variant for any of the oxidative stress variables.

Conclusions: We found that compared with CYBA polymorphisms C242T and A640G, it was aerobic exercise training that had the greatest influence on the selected biomarkers; furthermore, our results suggest that the C242T CYBA variant influences baseline levels of urinary 8-iso-PGF but not the aerobic exercise-induced responses.

©2009The American College of Sports Medicine

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.

Connect With Us