Evidence for a Greater Elevation in Vascular Shear Stress after Morning Exercise

JONES, HELEN1; GREEN, DANIEL J.1,2; GEORGE, KEITH P.1; BLACK, MARK A.1; ATKINSON, GREG1

Medicine & Science in Sports & Exercise:
doi: 10.1249/MSS.0b013e318195109c
Clinical Sciences
Abstract

Introduction: The vascular endothelium plays an important role in the maintenance of vascular health and the modulation of vascular tone and blood pressure. Recently, it has been demonstrated that blood pressure reactivity to physical activity is greater in the morning, and possibly, diurnal variation in vascular function may also be evident. The aim of this study was to assess vascular responses after exercise at different times of day.

Methods: After 45 min of supine rest, 12 male normotensives completed a 30-min bout of cycling at 70% peak oxygen uptake beginning on separate days at 0800 and 1600 h. Edge detection and wall tracking of high-resolution arterial B-mode ultrasound images combined with synchronized Doppler waveform analysis were used to measure brachial and femoral conduit artery diameter and to calculate blood flow and shear rate. Measurements were recorded before and 20 min after exercise.

Results: At 5 min after exercise, the mean ± SE brachial shear rate was 72 ± 21 arbitrary unit (AU) higher in the morning compared with the afternoon (P = 0.05), but this was not compensated for by enlargement of arterial diameter (P = 0.59). No diurnal variation was observed in the femoral artery measurements.

Conclusion: Diurnal difference in conduit artery regulatory control manifests as an elevated intravascular shear stress after morning exercise. Potentially, higher postexercise shear rate in the morning in at-risk individuals could contribute to the elevated cardiovascular risk evident in the postwaking hours.

Author Information

1Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UNITED KINGDOM; and 2School of Sports Science, Exercise and Health, The University of Western Australia, Crawley, Western Australia, AUSTRALIA

Address for correspondence: Helen Jones, Ph.D., Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Henry Cotton Campus, Webster Street, Liverpool L3 2ET, United Kingdom; E-mail: h.jones1@ljmu.ac.uk.

Submitted for publication September 2008.

Accepted for publication November 2008.

©2009The American College of Sports Medicine