The Effects of Regular Strength Training on Telomere Length in Human Skeletal Muscle


Medicine & Science in Sports & Exercise: January 2008 - Volume 40 - Issue 1 - pp 82-87
doi: 10.1249/mss.0b013e3181596695
BASIC SCIENCES: Original Investigations

Purpose: The length of DNA telomeres is an important parameter of the proliferative potential of tissues. A recent study has reported abnormally short telomeres in skeletal muscle of athletes with exercise-associated fatigue. This important report raises the question of whether long-term practice of sports might have deleterious effects on muscle telomeres. Therefore, we aimed to compare telomere length of a group of power lifters (PL; N = 7) who trained for 8 ± 3 yr against that of a group of healthy, active subjects (C; N = 7) with no history of strength training.

Methods: Muscle biopsies were taken from the vastus lateralis, and the mean and minimum telomeric restriction fragments (TRF) (telomere length) were determined, using the Southern blot protocol previously used for the analysis of skeletal muscle.

Results: There was no abnormal shortening of telomeres in PL. On the contrary, the mean (P = 0.07) and the minimum (P = 0.09) TRF lengths in PL tended to be higher than in C. In PL, the minimum TRF length was inversely correlated to the individual records in squat (r = −0.86; P = 0.01) and deadlift (r = −0.88; P = 0.01).

Conclusion: These results show for the first time that long-term training is not associated with an abnormal shortening of skeletal muscle telomere length. Although the minimum telomere length in PL remains within normal physiological ranges, a heavier load put on the muscles means a shorter minimum TRF length in skeletal muscle.

1Department of Health Sciences, Örebro University, Örebro, SWEDEN; 2Department of Clinical Medicine, Örebro University, Örebro, SWEDEN; and 3Institute of Sports Medicine, Bispebjerg Hospital, Copenhagen, DENMARK

Address for correspondence: Fawzi Kadi, Ph.D., Assistant Professor, Department of Health Sciences, Örebro University, 70182, Örebro, Sweden; E-mail:

Submitted for publication June 2007.

Accepted for publication August 2007.

© 2008 American College of Sports Medicine