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A Patient with Vanishing Lung Syndrome and Remarkable Tolerance to High Altitude


Medicine & Science in Sports & Exercise: November 2007 - Volume 39 - Issue 11 - p 1891-1895
doi: 10.1249/mss.0b013e318145b62d
CLINICAL SCIENCES: Clinical Case Studies

ABSTRACT Very little information is known about patients with chronic obstructive pulmonary disease who travel to high altitude for work or pleasure. Even less is known about the outcomes at high altitude for patients with severe bullous lung disease. We present the case of a 54-yr-old man with vanishing lung syndrome, an idiopathic form of severe bullous emphysema, who has made repeated trips to altitudes as high as 3400 m, where he has engaged in physical activity, such as downhill skiing. We consider the issues of adequacy of oxygenation and the risks of barotrauma in patients with obstructive lung disease traveling to high altitude, and we also consider factors, such as improved air-flow limitation, maintenance of adequate ventilation-perfusion matching, and underlying physical fitness, which may affect our patient's ability to tolerate physical activity in this environment. The case demonstrates that the presence of severe lung disease does not necessarily preclude travel to and moderate activity at high altitude. Such travel may, in fact, be safe as long as the patient has undergone appropriate pretravel evaluation, and we provide recommendations regarding such evaluation in patients with chronic obstructive pulmonary disease.

1Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA; 2Department of Medicine, University of California, San Diego, La Jolla, CA; and 3Division of Pulmonary and Critical Care Medicine, Puget Sound Veterans Health Care System, Seattle, WA

Address for correspondence: Andrew M. Luks, M.D., Acting Clinical Instructor, Pulmonary and Critical Care Medicine, 1959 NE Pacific Street Box 356522, Seattle, WA 98195-6522; E-mail:

Submitted for publication March 2007.

Accepted for publication June 2007.

©2007The American College of Sports Medicine