Skip Navigation LinksHome > November 2006 - Volume 38 - Issue 11 > Role of AMP-Activated Protein Kinase in the Molecular Adapta...
Medicine & Science in Sports & Exercise:
doi: 10.1249/01.mss.0000233798.62153.50
SYMPOSIUM: Training for Endurance and Strength: Lessons from Molecular Biology

Role of AMP-Activated Protein Kinase in the Molecular Adaptation to Endurance Exercise

WINDER, WILLIAM W.1; TAYLOR, ERIC B.2and ; THOMSON, DAVID M.1

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Abstract

What are the molecular signals induced by muscle contraction that result in an increase in GLUT4, hexokinase 2, mitochondrial oxidative enzymes, and other adaptations to endurance exercise training? Could repetitive activation of AMP-activated protein kinase (AMPK) be responsible in part? There is substantial evidence for a role of AMPK in inducing adaptations to endurance training: 1) AMPK is activated in response to muscle contraction; 2) chronic chemical activation of AMPK results in increases in GLUT4, hexokinase 2, UCP-3, and citric acid cycle enzymes; 3) muscle contraction and chemical activation of AMPK both result in increases in PGC-1α, a transcriptional coactivator involved in stimulation of mitochondrial biogenesis; and 4) increases in muscle PGC-1α, delta-aminolevulinic acid synthetase, and mitochondrial DNA induced by chronic creatine phosphate depletion in wild-type mice are not observed in dominant-negative AMPK mice. These observations lend credence to the hypothesis that AMPK activation induced by muscle contraction is responsible in part for adaptations to endurance exercise training.

©2006The American College of Sports Medicine

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