Skip Navigation LinksHome > November 2006 - Volume 38 - Issue 11 > Interaction between the AMP-Activated Protein Kinase and mTO...
Medicine & Science in Sports & Exercise:
doi: 10.1249/01.mss.0000233796.16411.13
SYMPOSIUM: Training for Endurance and Strength: Lessons from Molecular Biology

Interaction between the AMP-Activated Protein Kinase and mTOR Signaling Pathways

KIMBALL, SCOT R.

Collapse Box

Abstract

The AMP-activated protein kinase (AMPK) has been referred to as an "energy sensor" because it binds to and is regulated by both AMP and ATP. The binding of AMP to AMPK allows it to be phosphorylated by upstream kinases, resulting in its activation. In contrast, the binding of ATP prevents its activation. AMPK regulates a multitude of metabolic processes that cumulatively function to maintain cellular energy homeostasis through repression of a number of energy-consuming processes with simultaneous enhancement of energy-producing processes. One downstream AMPK target that has been recently identified is the mammalian target of rapamycin (mTOR), a positive effector of cell growth and division. The focus of the present review is to briefly summarize current knowledge concerning the regulation of mTOR signaling by AMPK.

©2006The American College of Sports Medicine

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.

Connect With Us