Gender Differences in the Fatigability of the Inspiratory Muscles

GONZALES, JOAQUIN U.; SCHEUERMANN, BARRY W.

Medicine & Science in Sports & Exercise: March 2006 - Volume 38 - Issue 3 - pp 472-479
doi: 10.1249/01.mss.0000189318.80061.fe
BASIC SCIENCES: Original Investigations

Purpose: The purpose of the present study was to determine whether gender differences are present in the fatigability of the inspiratory muscles of humans. Based on evidence for a gender difference in the oxygen cost of breathing, we hypothesized that females would result in a greater magnitude and/or faster rate of inspiratory muscle fatigue than males.

Methods: Eleven females and males (N = 22) performed resistive breathing at a target pressure of 70% of maximal inspiratory pressure (PImax). Rate of inspiratory muscle fatigue was calculated from measures of PImax taken every 2 min during resistive breathing, and recovery of inspiratory muscle strength was assessed up to 45 min following task failure.

Results: Resting PImax was found to be lower for females than males (F:137.0 ± 7.6 cm H2O; M:172.5 ± 9.8 cm H2O, mean ± SE, P ≤ 0.05). During resistive breathing, females exhibited a slower absolute and relative rate of muscle fatigue than males (F: 1.5 ± 0.4 cm H2O·min−1; M: −2.9 ± 0.3 cm H2O·min−1; P ≤0.05). Females and males resulted in a similar decrease in PImax at task failure (15%), and no gender difference was found for recovery of inspiratory muscle strength. Separate analyses were performed in a subgroup of females and males that were matched for resting PImax. Females demonstrated a slower rate of fatigue and less muscle fatigue at task failure than males. No gender difference was found in time to task failure or the recovery of inspiratory muscle strength.

Conclusion: The results provide some evidence that the fatigability of the inspiratory muscles is different between genders. Females demonstrated a slower rate of fatigue during resistive breathing than males, a finding independent of muscle strength.

Cardiopulmonary and Metabolism Research Laboratory, Department of Kinesiology, University of Toledo, Toledo, OH

Address for correspondence: Barry W. Scheuermann, PhD, Assistant Professor, Cardiopulmonary and Metabolism Research Laboratory, Department of Kinesiology, Health and Human Services Building, University of Toledo, Toledo, OH 43606; E-mail: barry.scheuermann@utoledo.edu.

Submitted for publication June 2005.

Accepted for publication September 2005.

©2006The American College of Sports Medicine